In Ethiopia many medicinal plants are used for the treatment of malaria including Dodonaea angustifolia seed without considering their side effects. The side effect of those medicinal plants can be evaluated by the use of the chronic treatment or acute treatment. In such a case laboratory animals were administered with the crude extracts of the plant through the oral route using oral gavage for at least six weeks at different doses. At the end of the experiment, all mice under treatment were sacrificed after blood collection for hematological and biochemical analysis and liver and kidney sections were randomly taken for tissue processing. The results of hematological and biochemical analysis as well as the microscopic examinations of the liver and kidney sections were compared with control groups.
Acetaminophen is widely used as an analgesic and antipyretic drug. Prolong daily use or overdose of this drug may cause acute liver and kidney damage. This book was designed to assist in the diagnosis of patients with liver and kidney damage of indeterminate etiology for which acetaminophen is suspected. Thus, this book intends to add to the list of drugs that can possibly be used in treatment of acetaminophen overdose.
Medical laboratories are essential components of the health system and their major role is measurement of substances in body fluid for the purpose of diagnosis, treatment, prevention, and for greater understanding of the disease process. To achieve these aims the data generated has to be reliable for which strict quality control, quality management and quality assurance have to be maintained. Medical laboratories in developing countries should be alleviated from lack of accuracy and precision through collaborative approach among different stakeholders and through strengthening them in equipments and continuously training human resources. The use of quality management system and close follow-up with quality control and quality assessment schemes are recommended.
Cyclosporin ‘A'' is the major component of the Cyclosporins, a group of nonpolar cyclic oligopeptides possessing immunosuppressive activity. Cyclosporin ‘A'' is used extensively in the prevention and treatment of graft-versus-host reactions in bone marrow transplantation and for the prevention of rejection of kidney, heart, and liver transplants. As its role in transplantation surgery increases, the demand on industry to improved yields intensifies. In order to obtain and maintain a competitive economic position for new and existing fermentation respectively, it is also necessary to find means for increasing the yields of the fermentation product. The present study has been designed to enhance production capability of Cyclosporin ‘A'' by local isolates of Aspergillus terreus by mutating the cultures with UV radiation and mutagenic chemicals.
In a search for better antidotes of metallic pollutants, many chemical (drugs) were evaluated. The aim of the present study was the evaluation and comparison the efficacy of two familiar antidotes DMSA and DMPS used for treatment of lead toxicity. The current study was designed to evaluate the efficacy of both DMSA and DMPS in treatment of long-term lead toxicity through assessment of hematological, biochemical, histopathological and levels of lead in some tissues (liver, kidney and brain) of exposed rats. One hundred twenty male albino rats were divided into four groups (30 each). The first group (C) was used as control, the 2nd, 3rd and 4th (L, D and P) were exposed to lead acetate in drinking water (100 ppm) for 12 weeks. Both D and P groups were treated with DMSA and DMPS respectively after 2, 4, 6, 8, 10, 12 weeks 24 hours prior to sampling. The investigated parameters were hematological picture, biochemical parameters (total protein, ALT, AST, ?–GT, LPO, NO and SOD), lead levels (liver, kidney and brain) and histopathological examination.
Leukemia is a broad term covering a spectrum of diseases. It is a part of the even broader group of diseases called hematological neoplasm. This study was undertaken to clarify the hematological and biochemical changes accompanied with leukemia induced experimentally in rats with benzene administration and its treatment using certain anticancer drugs such as Methotrexate and Doxorubicin. The biochemical parameters were widely investigated. The obtained results illustrated that some chemicals have a toxic effect on blood cells, bone marrow and body organs. such as liver, kidney and heart. Uses of anticancer drugs such as Methotrexate and Aldoxeirobsin in the treatment of blood cancer lead to liver toxicity and adverse effect on heart and increased rates of kidney functions, increase in some types of fat, lower rates for other natural and a lack of hemoglobin and increased oxidation of fat. Therefore we recommend avoiding toxic chemicals, especially benzene as possible and the work of analysis to complete blood sugar and liver function, kidney and fat and cardiac enzymes and analysis of the thyroid on a regular basis for patients with leukemia and cancer.
This study represents the pattern of kidney disease and their treatment in tertiary care hospitals in Bangladesh. To conduct the study i consulted the doctors nephrology department of National Institute of Kidney Diseases and Urology hospital to select patients for data collection.120 patients were selected, among which 68 were male and 52 were female. I found that, most of the kidney patient in acute &chronic renal diseases as a public health problem epidemiology, social, and economic implications. The impact of kidney disease on the global burden of diseases is probably underestimated by current methods of evaluation. However, kidney diseases are emerging as a major health problem. I also found that most of kidney patients were present with some other complication, of them hypertension renal disease, retinopathy neuropathy were the most common clinical complication of kidney disease. There is a paucity of data regarding the prevalence and clinical consequences of the chronic renal failure, maintenance dialysis, and renal transplant population in our country. The attendant complications of malaise wasting, anemia, and decreased immunity may predispose these patients to infection.
Bangladhonia (Eryngium foetdum L.) is a highly priced aromatic and medicinal culinary herb increasingly cultivated world wide. Seed - its production, rapid viability degradation and low germination rate limits its dissemination and cultivation. Experiments were conducted by the author at the Horticulture Field Laboratory of BSMRAU, Bangladesh to study morphology, fresh herb and seed production potentiality, seed storage and viability improvement. The dissertation includes method of Eryngium cultivation, morphological study, fresh herb and seed production, seed storage, viability and germination enhancement using growth regulators with different plant spacing. The highest seed yield (136.3kg/ha), gross return(BD Tk. 0.75 million/ha) and BCR (4.76) was recorded in 10?10 cm plant spacing. Seed treated with growth regulator solution (GA3 500ppm + Kinetin 50ppm) gave the maximum germination (31.23%), fresh yield (55.90 t/ha), gross return (BD Tk. 1.37 million/ha), gross margin (BD Tk. 1.18 million/ha) and BCR (8.52) with 20 kg seed/ha in broadcasting sowing system. Low temperature (4-5 deg.C) storage with air tight sealed polyethylene bag packaging was found better for storage of seeds.
This work on: 'Predicting the Longevity of Maize Seeds under Moisture-conditioned and Open Storage in Humid Tropical Seed Stores' aimed at evaluating the potential quality and storability of some commercial maize germplasm under humid tropical storage conditions. It was an attempt by the author to detail the physiological quality deterioration trends of maize seeds exposed to different storage environments and over a period of time. The study was carried out in the seed stores of The University of Agriculture, Abeokuta south west Nigeria and Institute of Agriculture Research and Training, Ibadan south west Nigeria during 2005/2006 and 2006/2007 seasons. The results showed evidence of seed deterioration in time; but with differences ranging from one seed storage environment to the other.This work confirmed the suitability of probit modeling in predicting seed longevity of agricultural crops.It can be concluded that ambient humid tropical conditions are not the best for seed storage of orthodox seeds.
The objective of the present study was to evaluate the effects of pesticide permethrin against frog Rana tigrina. After preliminary experiments of the under test compound, two different doses were selected for the studies. These were 1 and 0.1%. Mortality count was made at 24 hours of post-treatment, untreated frogs was also kept as well. Estimation of protein content and cholinesterase has been carried out in treated frogs and compared with untreated. It was observed that at the dose of 1 and 0.1% permethrin treated frogs, a total reduction in protein contents was found to be 61, 16% in kidney and 89 and 87% in liver, respectively. While cholinesterase was found to be inhibited by 35 and 6.76% in kidney and 29 and 23% in liver, respectively, when frog were treated with permethrin at aforesaid doses. On the basis of present study, it is concluded that the permethrin reduced protein contents and enzyme cholinesterase activity after 24 hours treatment in the liver and kidney frog Rana tigrina. The research techniques and information are helpful for graduate and research students of Biological Sciences and wildlife.
Doxorubicin (Adriamycin) is a well known anticancer drug used to cause cardiac damage in rats. In this book, combination of Enalapril and fenofibrate were assessed for cardioprotective effect. Parameters evaluated were ECG, blood pressure, serum markers viz. LDH, CK-MB, SGPT, SGOT, ALP, serum urea and serum creatinine. Tissue antioxidant markers viz. CAT and SOD, lipid peroxidation (MDA) for heart, liver and kidney and histopathological study of heart, liver and kidney. Parameters such as body weight, organ weight (heart, liver and kidney) and organ/body weight ratio were also evaluated.
The field of medical imaging has experienced a period of rapid development over the last 2 decade has consequently revolutionized the way in which modern medicine is practiced.The disease and their symptoms are highly varying and always a need for a continuous update of knowledge for the doctors and medical analyst.The diseases fall into different categories and a small variation of symptoms may leave to some other categories of diseases.The work concentrates on diagnosing diseases like cyst,fatty,Hepatoma, Hemangioma and Cirrhosis from ultrasound liver images.The contribution of this book relies on following areas: Pre-processing by speckle reduction, Image registration, feature extraction, classification & retrieval.This is further supplemented by the medical analyst for a continuous treatment process.This book provides an automated system that could retrieve ultrasound liver images based on user's interest to a level of providing decision support is of high need.This book helps for the medical analyst to take decision before treatment and planning surgery. It provides sound knowledge to researcher who are all working in problems involved in ultrasound medical imaging.