Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology. Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.
Knowledge of Artemisinin chemistry continues to move ahead on many fronts. This book is designed to provide a comprehensive coverage in the area of Artemisinin chemistry for the research and medical students. This book dealing with complex natural products such as Artemisin has presented many difficulties. I have tried to give a general indication of the problems involved and in doing so I have chosen, to a large extent, the most typical compounds for fairly detailed discussion. The practice of medicine now-a-days increasingly demands knowledge of the behaviour of molecules. I have attempted to give equal weight to the three fundamental aspects of the study of Artemisinin chemistry. The key features of this book are: Focuses on core knowledge and provides key concepts, facts and materials regarding Artemisin chemistry and their mechanisms. Enables the reader to grasp and understand the Artemisinin chemistry very quickly and easily. Several important concepts and cross-referencing in this book are put in the last part. This provides a unifying treatment. The material is selected and presented keeping in mind the needs of today’s medicinal chemistry research students.
Cancer is one of the most rapidly changing areas of medicine, affecting ever-increasing numbers of people, and this new edition of Lecture Notes: Oncology brings together all the information a medical student or graduate clinician needs in one accessible volume. It covers the scientific basis and social impact of cancer, describes the origins and presentations of cancer on a regional and system basis, and discusses the fundamentals of oncology treatment and patient management. Including a new section on epigenetics, clinical vignettes, clear illustrations, tables and diagrams, as well as a self-test section of MCQs, Lecture Notes: Oncology provides core knowledge for professionals involved in cancer care.
The virus, “Observe the virus; think how small, its arsenal, and yet how loud it call; It took my cell, now takes your cell, when it leaves will take our genes as well Genes that are master keys to growth, that turn it on, or turn it off or both; Should it return to me or you, it will own the skeleton keys to do; A number on our tumblers; stage a coup.” Viruses are a unique group of infectious agents whose distinctiveness resides in their simple, acellular organization and pattern of reproduction. Despite their simplicity in comparison with cellular organization, viruses are extremely important and deserving of close attention. The study of viruses has contributed significantly to the discipline of molecular biology-virology. This project focuses on the broader aspect of virology: the general properties & deals with characterization of virus, the ways in which viruses are cultured and studied. My project deals with “PCR based molecular identification of a begomovirus associated with yellow vein net disease of Amaranths”.
Oral cancer is one of the most common cancers in India. Tobacco and its various forms of consumption have resulted in a huge burden of oral cancers and precancerous conditions. This book summarizes the epidemiological studies conducted in India, with special emphasis on various tobacco practices in India, Cancer Prevention and strategies. Data from various epidemiological studies and cancer registries were also reported.
"I have cancer. Cancer does not have me."Sophie Sabbage was diagnosed with late-stage incurable lung cancer in October 2014. She was forty-eight years old, happily married with a four-year-old daughter. Since that day she has been on a remarkable journey of healing and transformation that has changed her life for the better. The Cancer Whisperer chronicles Sophie's extraordinary relationship with cancer and the methods that she has used for dealing with her fear, anger, denial, and grief. She offers a groundbreaking practical guide that will encourage cancer patients to:-Direct their own treatment while preserving their personhood -Engage with fear, anger, and grief in healthy and healing ways -Radically shift from being a cancer victim to seeing cancer less as a disease than as a symptom of other underlying causes
The urine is studied extensively by physiologist, bio-chemists, and bio-medical engineers, but it has not drawn much attention of physicists. The application of concepts, principles and techniques of physics for the solution of problems in biology at different levels of complexity to get internal picture is drawing the attention of many researchers. The aim of the work is to develop these ideas at molecular level by studying the Dielectric and biophysical properties of human urine at different physiological conditions. In the present work Dielectric and physical properties of urine such as specific gravity, refractive index, viscosity, surface tension, electrical conductivity and Fourier transform infrared spectroscopy has been studied for both normal subjects and physiological disorders.
The 2016 edition of Cracking the AP Chemistry Exam provides students with thorough subject reviews of all relevant topics, including atomic structure, thermodynamics, the periodic table, fundamental laws, organic chemistry, molecular binding, and key equations, laws, and formulas. It also includes helpful tables, charts, and diagrams and detailed advice on how to write a high-scoring essay.
Fungi: Biology and Applications, Second Edition provides a comprehensive treatment of fungi, covering biochemistry, genetics and the medical and economic significance of these organisms at introductory level. With no prior knowledge of the subject assumed, the opening chapters offer a broad overview of the basics of fungal biology, in particular the physiology and genetics of fungi and also a new chapter on the application of genomics to fungi. Later chapters move on to include more detailed coverage of topics such as antibiotic and chemical commodities from fungi, new chapters on biotechnological use of fungal enzymes and fungal proteomics, and fungal diseases of humans, antifungal agents for use in human therapy and fungal pathogens of plants.
This book presents conception of computer fundamental and contributions to computer science as written and recounted by those who made the contributions themselves. As such, it is a highly original approach to demonstrate an understating of the concepts in data communication in that they will be able to list and describe the function of communications hardware and software in the field of computer science. The scope of the book is broad in that it covers all aspects of computer science; evaluate the performance of a microcomputer based on the processor, memory, storage and other peripheral devices, discuss the changes in our society resulting from on-line services and the Internet and demonstrate an understanding of the role of the operating system in computer operations including file management.
Bladder cancer is a global health issue. In the endemic areas of Egypt, schistosomiasis is a leading cause of bladder cancer. Prognostic indicators are required to further identify which tumor should be treated aggressively early on, in order to improve surveillance. The Fas-Fas Ligand (Fas-FasL) system has been recognized as a major pathway for the induction of apoptosis in cells and tissues. Fas-mediated apoptosis is deeply involved in cancer cell death, brought about by the immune system. The interaction of Fas and Fas Ligand contributes to cytotoxic T-lymphocyte and natural killer-cell mediated cytotoxicity against cancer cells. This study was performed to assess the importance of the apoptosis markers (Fas and FasL) in bilharzial versus non-bilharzial bladder cancer, in order to detect the possible diagnostic &/or prognostic potentials of this factor.
Collating our current knowledge and the latest developments for enabling breakthrough discoveries, this book focuses on the synthesis and applications of materials that are based on supramolecular assemblies of carbon nanostructures, with an emphasis on fullerenes and nanotubes. In so doing, it provides readers with an overview of the different types of supramolecular architectures, accentuating the outstanding geometrical, electronic and photophysical properties of the building blocks and the resulting structures. It makes use of basic concepts and real-life applications – from simple syntheses to complex architectures, from instructive examples to working experimental procedures, and from photophysics to solar cells. A large part of each chapter is devoted to the methods and possibilities of controlling and tuning these molecular assemblies in order to obtain working devices. Fascinating reading for materials scientists, organic chemists, molecular physicists, and those in the semiconductor industry.
Lung cancer is the most deadly tumor, it causes more death than colorectal cancer, breast cancer, and prostate cancer combined.Approximately 75% of patients with lung cancer will have locally advanced or metastatic disease at the time of diagnosis and it has been estimated that about 30% of patients will develop obstruction of the airways at some point in their disease and that about 30% will die from pulmonary complications such as hypoxemia, hemoptysis or postobstructive pneumonia. Advances in bronchoscopic tools and techniques have provided interventional pulmonologists with a wide array of therapeutic options that can be used individually or in combination to match the needs of all patients. It is well proven now that restoring central airway patency has a significant impact on symptoms, pulmonary function, quality of life, and in selected patients even on survival.
Written by two well-known scholars in the field, Combinatorial Reasoning: An Introduction to the Art of Counting presents a clear and comprehensive introduction to the concepts and methodology of beginning combinatorics. Focusing on modern techniques and applications, the book develops a variety of effective approaches to solving counting problems. Balancing abstract ideas with specific topical coverage, the book utilizes real world examples with problems ranging from basic calculations that are designed to develop fundamental concepts to more challenging exercises that allow for a deeper exploration of complex combinatorial situations. Simple cases are treated first before moving on to general and more advanced cases. Additional features of the book include: • Approximately 700 carefully structured problems designed for readers at multiple levels, many with hints and/or short answers • Numerous examples that illustrate problem solving using both combinatorial reasoning and sophisticated algorithmic methods • A novel approach to the study of recurrence sequences, which simplifies many proofs and calculations • Concrete examples and diagrams interspersed throughout to further aid comprehension of abstract concepts • A chapter-by-chapter review to clarify the most crucial concepts covered Combinatorial Reasoning: An Introduction to the Art of Counting is an excellent textbook for upper-undergraduate and beginning graduate-level courses on introductory combinatorics and discrete mathematics.
The reactive nitrogen species peroxynitrite is a product of the reaction of nitric oxide with superoxide. This powerful oxidant has been proposed to contribute to the pathology of a large variety of diseases associated with increased inflammation and cancer development by its ability to oxidize and nitrate a variety of macromolecules. The transcription factor NF-?B is a predominant player in inflammatory and carcinogenic processes and has been found to play a major role in the transition from chronic inflammation to cancer initiation. In this study the molecular mechanisms by which NF-?B is activated under nitrative stress in a human colon cancer cell line and in colitis and human colon cancer sections of patients were investigated. The in vitro studies showed a dynamic, kinetic, and intensity activation of NF-?B caused by peroxynitrite, lead to an aberrant and belated pathway compared to the canonical activation by TNF-?. It occurred in a simultaneous dual mechanism: IKK dependent, by which p38 MAPK was found to be involved, and IKK independent. The clinical studies supported these findings with high activation of NF-kB and its target genes in colitis and colon cancer sections.