A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
Combinatorial optimization is a multidisciplinary scientific area, lying in the interface of three major scientific domains: mathematics, theoretical computer science and management. The three volumes of the Combinatorial Optimization series aim to cover a wide range of topics in this area. These topics also deal with fundamental notions and approaches as with several classical applications of combinatorial optimization. Concepts of Combinatorial Optimization, is divided into three parts: – On the complexity of combinatorial optimization problems, presenting basics about worst-case and randomized complexity; – Classical solution methods, presenting the two most-known methods for solving hard combinatorial optimization problems, that are Branch-and-Bound and Dynamic Programming; – Elements from mathematical programming, presenting fundamentals from mathematical programming based methods that are in the heart of Operations Research since the origins of this field.
With its use of multiple variables, functions, and formulas algebra can be confusing and overwhelming to learn and easy to forget. Perfect for students who need to review or reference critical concepts, Algebra I Essentials For Dummies provides content focused on key topics only, with discrete explanations of critical concepts taught in a typical Algebra I course, from functions and FOILs to quadratic and linear equations. This guide is also a perfect reference for parents who need to review critical algebra concepts as they help students with homework assignments, as well as for adult learners headed back into the classroom who just need a refresher of the core concepts. The Essentials For Dummies Series Dummies is proud to present our new series, The Essentials For Dummies. Now students who are prepping for exams, preparing to study new material, or who just need a refresher can have a concise, easy-to-understand review guide that covers an entire course by concentrating solely on the most important concepts. From algebra and chemistry to grammar and Spanish, our expert authors focus on the skills students most need to succeed in a subject.
This book focuses on new techniques, analysis, applications and future trends of microstrip and printed antenna technologies, with particular emphasis to recent advances from the last decade Attention is given to fundamental concepts and techniques, their practical applications and the future scope of developments. Several topics, essayed as individual chapters include reconfigurable antenna, ultra-wideband (UWB) antenna, reflectarrays, antennas for RFID systems and also those for body area networks. Also included are antennas using metamaterials and defected ground structures (DGSs). Essential aspects including advanced design, analysis and optimization techniques based on the recent developments have also been addressed. Key Features: Addresses emerging hot topics of research and applications in microstrip and printed antennas Considers the fundamental concepts, techniques, applications and future scope of such technologies Discusses modern applications such as wireless base station to mobile handset, satellite earth station to airborne communication systems, radio frequency identification (RFID) to body area networks, etc. Contributions from highly regarded experts and pioneers from the US, Europe and Asia This book provides a reference for R&D researchers, professors, practicing engineers, and scientists working in these fields. Graduate students studying/working on related subjects will find this book as a comprehensive literature for understanding the present and future trends in microstrip and printed antennas.
The pathways and networks underlying biological function Now in its second edition, Biochemical Pathways continues to garner praise from students, instructors, and researchers for its clear, full-color illustrations of the pathways and networks that determine biological function. Biochemical Pathways examines the biochemistry of bacteria, plants, and animals. It offers a quick overview of the metabolic sequences in biochemical pathways, the chemistry and enzymology of conversions, the regulation of turnover, the expression of genes, the immunological interactions, and the metabolic background of health disorders. A standard set of conventions is used in all illustrations, enabling readers to easily gather information and compare the key elements of different biochemical pathways. For both quick and in-depth understanding, the book uses a combination of: Illustrations integrating many different features of the reactions and their interrelationships Tables listing the important system components and their function Text supplementing and expanding on the illustrated facts In the second edition, the volume has been expanded by 50 percent. Text and figures have undergone a thorough revision and update, reflecting the tremendous progress in biochemical knowledge in recent years. A guide to the relevant biochemical databases facilitates access to the extensive documentation of scientific knowledge. Biochemical Pathways, Second Edition is recommended for all students and researchers in such fields as biochemistry, molecular biology, medicine, organic chemistry, and pharmacology. The book's illustrated pathways aids the reader in understanding the complex set of biochemical reactions that occur in biological systems. From the reviews: “… highly recommended for every scientist and student working in biochemistry.” –Umwelt & Gesundheit 4/2012 (review in German language)
This book provides an essential understanding of statistical concepts necessary for the analysis of genomic and proteomic data using computational techniques. The author presents both basic and advanced topics, focusing on those that are relevant to the computational analysis of large data sets in biology. Chapters begin with a description of a statistical concept and a current example from biomedical research, followed by more detailed presentation, discussion of limitations, and problems. The book starts with an introduction to probability and statistics for genome-wide data, and moves into topics such as clustering, classification, multi-dimensional visualization, experimental design, statistical resampling, and statistical network analysis. Clearly explains the use of bioinformatics tools in life sciences research without requiring an advanced background in math/statistics Enables biomedical and life sciences researchers to successfully evaluate the validity of their results and make inferences Enables statistical and quantitative researchers to rapidly learn novel statistical concepts and techniques appropriate for large biological data analysis Carefully revisits frequently used statistical approaches and highlights their limitations in large biological data analysis Offers programming examples and datasets Includes chapter problem sets, a glossary, a list of statistical notations, and appendices with references to background mathematical and technical material Features supplementary materials, including datasets, links, and a statistical package available online Statistical Bioinformatics is an ideal textbook for students in medicine, life sciences, and bioengineering, aimed at researchers who utilize computational tools for the analysis of genomic, proteomic, and many other emerging high-throughput molecular data. It may also serve as a rapid introduction to the bioinformatics science for statistical and computational students and audiences who have not experienced such analysis tasks before.
A guide to analyzing the structures and properties of organic molecules Until recently, the study of organic molecules has traveled down two disparate intellectual paths—the experimental, or physical, method and the computational, or theoretical, method. Working somewhat independently of each other, these disciplines have guided research for decades, but they are now being combined efficiently into one unified strategy. Molecular Structure delivers the essential fundamentals on both the experimental and computational methods, then goes further to show how these approaches can join forces to produce more effective analysis of the structure and properties of organic compounds by: Looking at experimental structures: electron, neutron, X-ray diffraction, and microwave spectroscopy as well as computational structures: ab initio, semi-empirical molecular orbital, and molecular mechanics calculations Discussing various electronic effects, particularly stereoelectronic effects, including hyperconjugation, negative hyperconjugation, the Bohlmann and anomeric effects, and how and why these cause changes in structures and properties of molecules Illustrating complex carbohydrate effects such as the gauche effect, the delta-two effect, and the external anomeric torsional effect Covering hydrogen bonding, the CH bond, and how energies, especially heats of formation, can be affected Using molecular mechanics to tie all of these things together in the familiar language of the organic chemist, valence bond pictures Authored by a founding father of computational chemistry, Molecular Structure broadens the scope of the subject by serving as a pioneering guide for workers in the fields of organic, biological, and computational chemistry, as they explore new possibilities to advance their discoveries. This work will also be of interest to many of those in tangential or dependent fields, including medicinal and pharmaceutical chemistry and pharmacology.
All life on earth occurs in natural assemblages called communities. Community ecology is the study of patterns and processes involving these collections of two or more species. Communities are typically studied using a diversity of techniques, including observations of natural history, statistical descriptions of natural patterns, laboratory and field experiments, and mathematical modelling. Community patterns arise from a complex assortment of processes including competition, predation, mutualism, indirect effects, habitat selection, which result in the most complex biological entities on earth – including iconic systems such as rain forests and coral reefs. This book introduces the reader to a balanced coverage of concepts and theories central to community ecology, using examples drawn from terrestrial, freshwater, and marine systems, and focusing on animal, plant, and microbial species. The historical development of key concepts is described using descriptions of classic studies, while examples of exciting new developments in recent studies are used to point toward future advances in our understanding of community organization. Throughout, there is an emphasis on the crucial interplay between observations, experiments, and mathematical models. This second updated edition is a valuable resource for advanced undergraduates, graduate students, and established scientists who seek a broad overview of community ecology. The book has developed from a course in community ecology that has been taught by the author since 1983. Figures and tables can be downloaded for free from www.wiley.com/go/morin/communityecology
A comprehensive overview of functional nanosystems based on organic and polymeric materials and their impact on current and future research and technology in the highly interdisciplinary field of materials science. As such, this handbook covers synthesis and fabrication methods, as well as properties and characterization of supramolecular architectures. Much of the contents are devoted to existing and emerging applications, such as organic solar cells, transistors, diodes, nanowires and molecular switches. The result is an indispensable resource for materials scientists, organic chemists, molecular physicists and electrochemists looking for a reliable reference on this hot topic.
A Companion to Plutarch offers a broad survey of the famous historian and biographer; a coherent, comprehensive, and elegant presentation of Plutarch’s thought and influence Constitutes the first survey of its kind, a unified and accessible guide that offers a comprehensive discussion of all major aspects of Plutarch’s oeuvre Provides essential background information on Plutarch’s world, including his own circle of influential friends (Greek and Roman), his travels, his political activity, and his relations with Trajan and other emperors Offers contextualizing background, the literary and cultural details that shed light on some of the fundamental aspects of Plutarch’s thought Surveys the ideologically crucial reception of the Greek Classical Period in Plutarch’s writings Follows the currents of recent serious scholarship, discussing perennial interests, and delving into topics and works not formerly given serious attention
Addressing the fundamental technologies and theories associated with designing complex communications systems and networks, Principles of Communications Networks and Systems provides models and analytical methods for evaluating their performance. Including both the physical layer (digital transmission and modulation) and networking topics, the quality of service concepts belonging to the different layers of the protocol stack are interrelated to form a comprehensive picture. The book is designed to present the material in an accessible but rigorous manner. It jointly addresses networking and transmission aspects following a unified approach and using a bottom up style of presentation, starting from requirements on transmission links all the way up to the corresponding quality of service at network and application layers. The focus is on presenting the material in an integrated and systematic fashion so that students will have a clear view of all the principal aspects and of how they interconnect with each other. A comprehensive introduction to communications systems and networks, addressing both network and transmission topics Structured for effective learning, with basic principles and technologies being introduced before more advanced ones are explained Features examples of existing systems and recent standards as well as advanced digital modulation techniques such as CDMA and OFDM Contains tools to help the reader in the design and performance analysis of modern communications systems Provides problems at the end of each chapter, with answers on an accompanying website
This self-contained handbook and ready reference examines aerosol science and technology in depth, providing a detailed insight into this progressive field. As such, it covers fundamental concepts, experimental methods, and a wide variety of applications, ranging from aerosol filtration to biological aerosols, and from the synthesis of carbon nanotubes to aerosol reactors. Written by a host of internationally renowned experts in the field, this is an essential resource for chemists and engineers in the chemical and materials disciplines across multiple industries, as well as ideal supplementary reading in graduate level courses.
Providing a comprehensive grounding in the subject of turbulence, Statistical Theory and Modeling for Turbulent Flows develops both the physical insight and the mathematical framework needed to understand turbulent flow. Its scope enables the reader to become a knowledgeable user of turbulence models; it develops analytical tools for developers of predictive tools. Thoroughly revised and updated, this second edition includes a new fourth section covering DNS (direct numerical simulation), LES (large eddy simulation), DES (detached eddy simulation) and numerical aspects of eddy resolving simulation. In addition to its role as a guide for students, Statistical Theory and Modeling for Turbulent Flows also is a valuable reference for practicing engineers and scientists in computational and experimental fluid dynamics, who would like to broaden their understanding of fundamental issues in turbulence and how they relate to turbulence model implementation. Provides an excellent foundation to the fundamental theoretical concepts in turbulence. Features new and heavily revised material, including an entire new section on eddy resolving simulation. Includes new material on modeling laminar to turbulent transition. Written for students and practitioners in aeronautical and mechanical engineering, applied mathematics and the physical sciences. Accompanied by a website housing solutions to the problems within the book.
Essentials of Pharmaceutical Preformulation is a study guide which describes the basic principles of pharmaceutical physicochemical characterisation. Successful preformulation requires knowledge of fundamental molecular concepts (solubility, ionisation, partitioning, hygroscopicity and stability) and macroscopic properties (physical form, such as the crystalline and amorphous states, hydrates, solvates and co-crystals and powder properties), familiarity with the techniques used to measure them and appreciation of their effect on product performance, recognising that often there is a position of compromise to be reached between product stability and bioavailability. This text introduces the basic concepts and discusses their wider implication for pharmaceutical development, with reference to many case examples of current drugs and drug products. Special attention is given to the principles and best-practice of the analytical techniques that underpin preformulation (UV spectrophotometry, TLC, DSC, XRPD and HPLC). The material is presented in the typical order that would be followed when developing a medicine and maps onto the indicative pharmacy syllabus of the Royal Pharmaceutical Society of Great Britain Undergraduate-level pharmacy students and R&D / analytical scientists working in the pharmaceutical sector (with or without a pharmaceutical background) will find this text easy to follow with relevant pharmaceutical examples. Essential study guide for pharmacy and pharmaceutical science students Covers the pharmaceutical preformulation components of the Royal Pharmaceutical Society of Great Britain’s indicative syllabus Easy to follow text highlighted with relevant pharmaceutical examples Self-assessment assignments in a variety of formats Written by authors with both academic and industrial experience Companion website with further information to maximise learning
Understanding the reactivity of monomers is crucial in creating copolymers and determining the outcome of copolymerization. Covering the fundamental aspects of polymerization, Synthesis and Applications of Copolymers explores the reactivity of monomers and reaction conditions that ensure that the newly formed polymeric materials exhibit desired properties. Referencing a wide-range of disciplines, the book provides researchers, students, and scientists with the preparation of a diverse variety of copolymers and their recent developments, with a particular focus on copolymerization, crystallization, and techniques like nanoimprinting and micropatterning.