The classic and authoritative textbook, Molecular Mechanisms of Photosynthesis,is now fully revised and updated in this much-anticipated second edition. Whilst retaining the first edition’s clear writing style and accessible description of this complex process, updates now include cutting-edge applications of photosynthesis, such as to bioenergy and artificial photosynthesis as well as new analytical techniques. Written by a leading authority in photosynthesis research, this new edition is presented in full color with clear, student-friendly illustrations. An interdisciplinary approach to photosynthesis is taken, with coverage including the basic principles of energy storage, the history and early development of photosynthesis, electron transfer pathways, genetics and evolution. A comprehensive appendix, containing an introduction to the basic chemical and physical principles involved in photosynthesis, is also included. Molecular Mechanisms of Photosynthesis,second edition, is an indispensable text for all students of plant biology, bioenergy, and molecular biology, in addition to researchers in these and related fields looking for an accessible introduction to this vital and integral process to life on earth. stresses an interdisciplinary approach emphasizes recent advances in molecular structures and mechanisms includes the latest insights and research on structural information, improved techniques as well as advances in biochemical and genetic methods comprehensive appendix, which includes a detailed introduction to the physical basis of photosynthesis, including thermodynamics, kinetics, and spectroscopy associated website with downloadable figures as powerpoint slides for teaching
Regeneration of the periodontal tissues is a complex phenomenon requiring interplay between various processes in a timely manner.Research strives to attain regeneration in a more predictable, quicker, less invasive ways than allowed by previous techniques. Tissue engineering is a highly promising field of reconstructive biology that draws on recent advances in medicine, surgery, molecular and cellular biology, polymer chemistry and physiology. The objective of using tissue engineering as therapeutic application has been to harness its ability to exploit selected and primed cells together with an appropriate mix of regulatory factors, to allow growth and specialization of cells and matrix. This book is a brief review on the basics of tissue engineering related to Periodontology and also updates the reader with the controlled clinical trials that prove the ability of tissue engineering in achieving new heights in periodontal regeneration.
Synthetic oligonucleotides act as a fuel for engine of modern molecular biology. One of the major application of these biomolecules is in construction of oligonucleotide microarrays or biochips. Microarrays are monolithic, flat surfaces that bear multiple probe sites and each bear a reagent whose molecular recognition of a complementary molecule can result to a signal that is detected by an imaging technology, most often fluorescence. Large-scale genotyping, gene-expression profiling, and disease diagnosis are some of the main applications of biochips. At the present time, this technology of arrayed nucleic acids is employed in many areas, from genetics to molecular medicine to industrial production. This book will give you an insight to efficient strategies for microarray fabrication using modified/unmodified oligonucleotides and glass microslides. In addition, chemical reagents for the estimation of functional group density on solid supports are discussed.
The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.
A comprehensive, authoritative look at an emergent area in post-genomic science, Evolutionary genomics is an up-and-coming, complex field that attempts to explain the biocomplexity of the living world. Evolutionary Genomics and Systems Biology is the first full-length book to blend established and emerging concepts in bioinformatics, evolution, genomics, and structural biology, with the integrative views of network and systems biology. Three key aspects of evolutionary genomics and systems biology are covered in clear detail: the study of genomic history, i.e., understanding organismal evolution at the genomic level; the study of macromolecular complements, which encompasses the evolution of the protein and RNA machinery that propels life; and the evolutionary and dynamic study of wiring diagrams—macromolecular components in interaction—in the context of genomic complements. The book also features: A solid, comprehensive treatment of phylogenomics, the evolution of genomes, and the evolution of biological networks, within the framework of systems biology A special section on RNA biology—translation, evolution of structure, and micro RNA and regulation of gene expression Chapters on the mapping of genotypes to phenotypes, the role of information in biology, protein architecture and biological function, chromosomal rearrangements, and biological networks and disease Contributions by leading authorities on each topic Evolutionary Genomics and Systems Biology is an ideal book for students and professionals in genomics, bioinformatics, evolution, structural biology, complexity, origins of life, systematic biology, and organismal diversity, as well as those individuals interested in aspects of biological sciences as they interface with chemistry, physics, and computer science and engineering.
Developmental biology is at the core of biological science, integrating molecular biology, genetics and anatomy. The past 15 years has seen revolutionary advances not only in our understanding of the processes by which an egg develops into an adult, but also in the application of this knowledge to the areas of reproductive technology, drug development and organ replacement. Essential Developmental Biology is a concise and well-illustrated treatment of this subject for undergraduates. Assuming no prior knowledge of anatomy and only the basics of cell biology and genetics, the book starts off by introducing the principles and approaches of developmental biology. The second section covers the characteristic development of each of the principal model species used for research and the final chapters are devoted to organ development, predominantly in vertebrates. With an emphasis throughout on the evidence underpinning the main conclusions, this book is suitable as the key text for both introductory and more advanced courses in developmental biology. A new approach to a widely taught subject. Priced for student purchase at approximately half the price of the main competition. Over 200 illustrations, with artwork available free on the Web. Well-known author/media celebrity.
In this world Individual and families who face a diagnosis of cancer face varying levels of stress and emotional upset. Cancer can be a very isolating experience. Disease like cancer develops the feelings of depression, frustration, hopelessness, loneliness and restlessness in the patients. The economic burden on the patients and their families for cancer treatment may disturb their financial condition. The present study is intended to explore the social and psychological impact of cancer on the patients and their families. The sample will be drawn from the three hospitals namely Nishtar Hospital, Minnar Hospital and Children Complex in Multan. These three hospitals have been purposively selected where contact with cancer patients will be possible for the researcher. The sample size will be of 60 cancer patients and 60 their families.
Synthetic biology is the construction of artificial biological systems, such as programmable cells, using principles from engineering, electronics, computer science and computational biology. Using biological circuit, we can produce a new concentration gradient that has twice the frequency. If 1 is represented by a concentration of the chemical within the threshold, and a 0 is represented by a concentration outside the threshold, then we can represent any two digit binary number. Thus, we can differentiate separate regions at certain distances away from a point source. The focus of these early studies was on using digital models as a way of understanding events in the living cell. The Boolean approximation was a way of avoiding an unwieldy analysis of a complex chemical web. To follow all those molecular interactions in complete detail would have required tracking the concentrations of innumerable molecular species, measuring the rates of chemical reactions, and solving hundreds of coupled differential equations. Either pretending that every gene is on or off reduced the problem to a simpler digital abstraction.
The book presents the results of crystal structure and conformational analysis of some organic compounds using X-ray diffraction. Single crystal X-ray diffraction has a powerful tool for accurate determination of molecular structure of all types of materials ranging from simple ionic crystals to macromolecules, at atomic resolution. It also has a very powerful tool for various interdisciplinary fields like physics, chemistry, metallurgy, mineralogy, molecular biology, drug design etc. The knowledge of accurate molecular structures and conformation would provide a better understanding of the structure-function relationship of the new compounds. This book consists of six chapters dealing with the crystallographic work on some acetamide, primidine, isoxazolidine, acrylic, oxygen containing heterocyclic and chlorophenyl derivatives. In this six chapters totally 13 structures were determined out of that 12 were published in International Union of Crystallography (IUCR) Journals.
Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process of carcinogenesis. The chemopreventive effects elicited by these natural dietary compounds are believed to include antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest. Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds. This book presents some theoretical issues, reviews, and a variety of concept of regarding basic cancer chemoprevention in different arena of cancer science.
This book is for Engineering students. It introduces the fundamental knowledge and overall concepts of steering technology. Analysis of concepts and fundamental knowledge can be utilized to develop practicality about steering mechanism. The book has evolved from the whole concept of steering after a detailed study on steering mechanism. Hence it is an intermediate textbook. It consist of steering concepts, steering design, steering dynamics and future improvements in the technology of steering. The connotation of the book have been kept it fairly paper and practical work. Each and every concept is highly demonstrative and elucidated, all the related approaches and formal proofs have been refined.
The valley of Kashmir is one of the divisions of Jammu and Kashmir State, situated in the Himalayas. In Kashmir valley where incidences of almost all types of organ cancers have shown a drastic increase in last couple of decades particularly GIT and lung cancers, the bladder cancer figures no less in this deadly race. As the valley of Kashmir is heavily burdened with cancers and the molecular aspects still remain unexplored to a large extent. This book is thoroughly research based to find the incidence of common cancers and first initiative to investigate the role of major oncogenes in urinary bladder cancer.The book may also be of interest to busy clinicians who want to update their knowledge of recent advances in bladder cancer biology and how these may apply to future practice. This book is designed as a primer for those who are involved with bladder cancer patients or the study of cancer. It is intended to supply sufficient background knowledge to allow the reader to seek more detailed information from the numerous textbooks and web resources in bladder oncology The aim and scope of this book is to provide readers with a comprehensive understanding of carcinogenesis.
This book is a contribution to the debate on the implications of the information theory of quantum systems for the description of numerous quantum phenomena of the electronic structure. It contains several applications of the basic concepts, techniques, and relations of the information theory to selected problems of atomic and molecular structure and chemical reactivity. Such treatment gives rise to the information-entropic representation of the atomic and molecular states, which complements the familiar energy representaton of the density-functional and wave-function-based theories. The most important role in this treatment is played by the concepts of information, complexity, and divergence.
Gene therapy considered to be a technology based on advancements in molecular biology originally conceived as an approach to treat autosomal recessive Mendelian disorders, now being applied to a broad range of acquired conditions such as cancers, infections and degenerative disorders. At the beginning of the nineties, much of this young field was based on a relatively simple concept: a deficient function can be replaced with an artificial gene. For twenty years now, gene therapists have been learning how wide the gap is between a concept and its practical reality. It will be of interest over the next few years to analyze whether clinical results will reach the expectations in this domain bearing in mind the lessons of gene therapy for cancer. The treatment of cancer, makes up almost 60 to 70% of the gene therapy trials worldwide, and includes some very elegant approaches.