Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology – two fields that enhance, move, and evolve into each other continuously. It provides an informative study in designing approaches to apply stem cell principles to cancer biology while offering an overview of the challenges in developing combination stem and cancer biology targets for therapeutics. This book serves as a primer for new researchers in the field of cancer biology.
Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how the theory translates to tackling the disease.
The book presents the principles of cancer biology in an organized, cogent, and in-depth manner. The book deals with What Is Cancer, Profile of a Cancer Cell, How Cancers Spread, Identifying the Causes of Cancer, Chemicals and Cancer, Radiation and Cancer, Infectious Agents and Cancer, Heredity and Cancer, Oncogenes, Tumor Suppressor Genes and Cancer Overview, Cancer Screening, Diagnosis, and Treatment, Preventing Cancer, Main Types of Cancer, Human Carcinogens. For all readers interested in the big picture view of cancer. The text can be used either as a first step towards a deeper understanding of the mechanisms of cancer progression or it can be used as a quick revision guide. It would be suitable for anyone, with or without a background in biology.The book includes many recent and topical references, and is intended to empower the student to move directly into the primary research literature.
Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.
Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials.Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.- Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work- Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system- Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases- Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays
This particular book “Cancer a class of dreaded diseases- its challenges and remedies” incorporates in all ten important topics of recent interest on cancer such as Introduction, Historical perspectives of cancer, Mechanisms of Development of cancer and Mechanisms of action of therapeutics, Tools and Techniques for Detection and diagnosis of Cancer, Nutritional difficulties and remedies during cancer, Various available cancer therapies, Various Challenges and remedies of Cancer, Prevention and Control of cancer, Future prospects of cancer Management, and Selected References. Important and intrinsic details of all aspects of cancer are covered in this book. It is expected that this book will be useful to oncobioology subject in particular and Life Sciences, Applied Biology, students at graduate and post graduate level as well as to teachers and research scholars in general.
We are now at an exciting era when our increased understanding of cancer biology jointly with the rapid advances in biotechnologies are allowing us to test fundamental concepts in cancer and ultimately translate them into the evolution of targeted cancer therapy. Resistance to cell death, especially to apoptosis, is an important feature of tumor cells, which is also described as one of the hallmarks in cancer. The research presented in this book supports the concept that apoptosis induction in tumor cells is a vital player in anticancer therapies. Although we already have a good knowledge of apoptosis machinery in cancer, various seemingly unrelated pathways (for example PAI-1 - uPA system) may also have linked to this important hallmark of cancer. Overall, a thorough understanding about cancer biology including taking tumor microenvironment into consideration is the foundation for the development of “targeted cancer therapy”.
Helps researchers in proteomics and oncology work together to understand, prevent, and cure cancer Proteomic data is increasingly important to understanding the origin and progression of cancer; however, most oncologic researchers who depend on proteomics for their studies do not collect the data themselves. As a result, there is a knowledge gap between scientists, who devise proteomic techniques and collect the data, and the oncologic researchers, who are expected to interpret and apply proteomic data. Bridging the gap between proteomics and oncology research, this book explains how proteomic technology can be used to address some of the most important questions in cancer research. Proteomic Applications in Cancer Detection and Discovery enables readers to understand how proteomic data is acquired and analyzed and how it is interpreted. Author Timothy Veenstra has filled the book with examples—many based on his own firsthand research experience—that clearly demonstrate the application of proteomic technology in oncology research, including the discovery of novel biomarkers for different types of cancers. The book begins with a brief introduction to systems biology, explaining why cancer is a systems biology disease. Next, it covers such topics as: Mass spectrometry in cancer research Application of proteomics to global phosphorylation analysis Search for biomarkers in biofluids Rise and fall of proteomic patterns for cancer diagnostics Emergence of protein arrays Role of proteomics in personalized medicine The final chapter is dedicated to the future prospects of proteomics in cancer research. By guiding readers through the latest proteomic technologies and their applications in cancer research, Proteomic Applications in Cancer Detection and Discovery enhances the ability of researchers in proteomics and researchers in oncology to collaborate in order to better understand cancer and develop strategies to prevent and treat it.
“… Useful background information is displayed in blue boxes, and good use is made of numerous tables and diagrams… a useful book for the undergraduate medical or allied health professional…” –Oncology News, May/June 2010 This forward looking cancer biology book appeals to a wide ranging audience. Introductory chapters that provide the molecular, cellular, and genetic information needed to comprehend the material of the subsequent chapters bring unprepared students up to speed for the rest of the book and serve as a useful refresher for those with previous biology background. The second set of chapters focuses on the main cancers in terms of risk factors, diagnostic and treatment methods and relevant current research. The final section encompasses the immune system’s role in the prevention and development of cancer and the impact that the Human Genome Project will have on future approaches to cancer care. While best suited to non-majors cancer biology courses, the depth provided satisfies courses that combine both majors and non-majors. Also, and deliberately, the authors have incorporated relevant information on diagnosis and treatment options that lend appeal to the lay reader.
Cancer being a highly complex combination of diseases, it can be studied and understood better by the complex networks in System/Network biology. Here is a novel step to study the relation between drug target network and the corresponding drug network using the advanced concept of proteomics and systems biology and to develop an effective strategy for cancer prevention.104 antimutagens were collected from literature survey. Of this only 81 structure were available and taken from the Pubchem database. The PDB ids of the Breast cancer genes were taken. Docking was performed with the help of Quantum docking software and the docking scores were obtained. The list of gene ids obtained is loaded into the VISANT application. From the data obtained and the various analysis done the antimutagen Beta-Sitosterol obtained from the Black cumin Seeds (Nigella Sativa) shows least RMSD value with the protein 2I1J corresponding to the gene UTP14A indicating that Breast cancer specific drugs are specific for the particular disease gene and not random among the networks. The ligands (Antimutagens) show good response to the specific type of cancer.
Over 99% of the world's population is infected with at least one potentially cancer-causing organism. It is vital for nurses and other healthcare professionals to be aware of the extent of infection-associated cancer and of how they can contribute to prevention of such cancers. Infectious Causes of Cancer, aimed principally at nurses and other healthcare professionals, considers the epidemiology and biology of infectious causes of cancer. It examines each of the infectious agents associated with an increased risk of cancer, discussing epidemiology of the infection and cancer, pathophysiology of the cancer, mechanisms, associated risk factors, and prevention of the infection and cancer. Key Features: A comprehensive and accessible guide to infection associated cancer and how to contribute to prevention A must-have for students or healthcare professionals working in oncology, primary care or health promotion Brings together all the up-to-date science, evidence and research related to infections and cancer in one publication
Radiotherapy is the most common modality for treating human cancers.Eighty percent of cancer patients need radiotherapy, either for curative or palliative purpose. Chemical modification is the concept in cancer therapy in which the state of tumor cells or normal tissues is modified such that the therapeutic gain can be achieved using conventional modalities. Radiosensitizers are the drugs that make cancer cells more sensitive to the effects of radiation therapy. Radioprotectors (also called radioprotectants) are drugs that protect normal (non cancerous) cells from the damage caused by radiation therapy. Therefore ,chemical modifier field is developing novel approaches to the cancer treatment and increasing the understanding of the basics of cancer biology.
When the woman he loved was diagnosed with a metastatic cancer, George Johnson set out to learn everything he could about the disease and the people who spend their careers trying to understand and to fight it. Deftly excavating and illuminating decades of investigation and analysis, rooted in every discipline from evolutionary biology to game theory and physics, Johnson explores what we know--and what we still don't--about cancer, and why a cure remains such a slippery concept. Throughout his pursuit, Johnson clarifies the human experience of cancer with grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. For anyone whose life has been touched by cancer, this book provides a new understanding through Johnson's radiant prose and authoritative eye-opening perspective on science.
Breast cancer is the most common cancer in women worldwide. Understanding the biology of this tumor is a prerequisite for selecting an appropriate treatment. Cell cycle alterations are seen in many cancers such as breast cancer. Newly popular targeted agents in breast cancer have been reported such as cyclin dependent kinase inhibitors (CDKIs) which are agents inhibiting the function of cyclin dependent kinases (CDKs) as well as Notch, Wnt, SHH (Sonic hedgehog) which have recently been reported as a novel therapeutic target in breast cancer. They are categorized as selective and non-selective inhibitors of CDK. CDKIs have been tried as monotherapy and combination therapy. Palbocyclib is now a promising CDKI used in breast cancer. Nowadays palbocyclib is designed for a phase III trial for estrogen receptor (ER) positive breast cancer after showing favorable results in progression free survival in a phase II trial. The tumor microenvironment is increasingly recognized as a significant factor in cancer treatment response. The tumor microenvironment is considered as a target for combination therapy of breast cancer.
Cancer is the only disease that is a severe threat and a dark fear to mankind for many centuries. Cancer being a highly complex combination of diseases, it can be studied and understood better by the complex networks in Systems Biology & Network pharmacology approach. Here is a novel step to study the relation between drug target network and the corresponding drug network using the advanced concept of proteomics and systems biology and to develop an effective strategy for cancer prevention. We constructed gene co-expression networks and identified the globally cancer-related genes by network structure analysis. To study the properties of networks, modules were identified and their functions and roles were investigated. Our results showed that the inferred networks were structurally conservative and the identified modules were highly overlapped between various data sets. From this network the different interactions of the ligands and the proteins were observed. From the data obtained and the various analysis done the antimutagen Beta-Sitosterol obtained from the Black cumin Seeds (Nigella Sativa) shows least RMSD value with the protein 2I1J corresponding to the gene UTP14A.