The book represents the English version, with modifications and additions, of the university course entitled "Kinetotherapy in cardiovascular diseases" published by “Alexandru Ioan Cuza” University Publishing House, Iasi, Romania, in 2014, the author Bogdan-Alexandru Hagiu. Is addressed to physical therapy specialists, providing basic information about cardiovascular diseases and their possible treatments. The last chapter, "The role of isometric contractions in treating cardiovascular disease" includes therapeutic applications of barbell-expander devices, invented by the author.
Role of ubiquitin has been observed in cardiovascular diseases. An overview of the various ubiquitin ligases involved in cardiovascular diseases is given. Their structure in Cn3D is also shown. This book aims at proposing models using ubiquitin which might be worked upon later and research can be carried out on those which could prove very beneficial in the future in treatment or prevention of cardiovascular diseases.
Cardiovascular diseases are the leading cause of death in patients on chronic dialysis. Numerous epidemiologic researches have proved a significant frequency of cardiovascular diseases in patients with chronic kidney disease. Multicentric studies have shown great incidence of cardiovascular complications in patients on dialysis. Patients with chronic kidney diseases have 10-20 times greater risk of developing cardiovascular disease in comparison to general population. Risk for starting cardiovascular diseases can be differentiated in patients on continuous ambulatory peritoneal dialysis and patients on hemodialysis, especially in patients who remain on peritoneal dialyses for more than two years and loose the remaining kidney function. Part of cardiovascular damage in patients treated with dialyses is caused by the use of residual renal therapy and question which therapy is more harmful, hemodialysis or peritoneal is very important. Despite the importance of the subject only several studies have been done in comparing cardiovascular test of patients treated with peritoneal dialyses and patients treated by hemodialysis. Our research deals with this issue in particular.
In this study, the physiological and molecular effects of two cholesterol lowering agents , synthetic statin (atorvastatin) and natural statin (simvastatin) on diabetic and hypercholesterolemic adult male Wistar albino rats (Rattus norvegicus)at two doses, 10 and 40 mg/kg, for 8 weeks was investigated. Other physiological parameters were evaluated under this investigation, like: glucose, urea, uric acid, creatinine, total protein, albumin, globulin, A/G ratio, total, direct and indirect billirubin) To assess the beneficial effect of the drugs on liver genomic DNA, the (RE) analysis with 5 restriction endonucleases manifested variations in DNA digestion patterns in diabetic and hypercholesterolemic rats treated with atorvastatin and simavstatin. Such variation reflects and clarifies a restoration and repairing effect of statin on rat liver DNA in diabetic and hypercholesterolemic rats.
In modern world, the major causes of death and disability are found to be shifted from nutritional deficiencies and infectious diseases to non-infectious chronic diseases. Technological advancement, socio-economical transition and change in life style like taking high energy food and sedentary life are found to be associated with increased prevalence of cardiovascular disorders in the World.Clinical care of cardiovscular disorders is costly and prolonged. These diseases in adult hood are largely due to behavior initiated in adolescence like physical inactivity, tobacco and alcohol use, unhealthy diet.Adolescents in India are adopting unhealthy life style in recent years and various studies have shown that risk factors of CVDs are also increasing in Indian adolescents.In this book, risk factor and its prevelance were explored in school going children and also biostatastically analysed for thier significance. This book will direct the ways towards the more epidemiological studies to reflects the changing scenario of cardiovascular diseases in current era.
The association between dental and cardiovascular diseases appears to be indirect or circumstantial and the results from previous studies connecting dental diseases to cardiovascular diseases are inconsistent. The aim in this cross-sectional study was to investigate whether there are associations between dental and cardiovascular diseases when adjusted for other predictors. This study indicated that the number of missing teeth showed a possible association with history of stroke. Number of carious tooth surfaces and gingival bleeding were found to be associated with history of congestive heart failure. Heart attack was shown to be associated with the number of missing teeth; in the sub-sample, heart attack did not show an association with any of the dental diseases. Association between periodontal pockets and cardiovascular diseases was not shown in this study. Additional studies are suggested to determine the nature of the relationship between the oral and cardiovascular diseases. Laboratory measures of infection and clinical evaluations should be used in longitudinal studies for further investigations.
Cardiovascular diseases remain a paramount focus of basic and clinical investigation. They are the leading cause of death in developed countries and their prevalence is increasing in the developing countries. Early detection of the formation and progression of atherosclerotic plaques is therefore essential. Proteomics is a tool designed to address this need at the level of signal transduction, organelle and cellular mechanism and biomarker development. This review examines the increasing use of traditional and novel biomarkers that are transforming cardiovascular medicine.
Heart disease or cardiovascular disease are the class of diseases that involve the heart or blood vessels (arteries and veins). While the term technically refers to any disease that affects the cardiovascular system (as used in MeSH C14), it is usually used to refer to those related to atherosclerosis (arterial disease). These conditions usually have similar causes, mechanisms, and treatments.Most countries face high and increasing rates of cardiovascular disease. Each year, heart disease kills more Americans than cancer. In recent years, cardiovascular risk in women has been increasing and has killed more women than breast cancer. A large histological study (PDAY) showed vascular injury accumulates from adolescence, making primary prevention efforts necessary from childhood. By the time that heart problems are detected, the underlying cause (atherosclerosis) is usually quite advanced, having progressed for decades. There is therefore increased emphasis on preventing atherosclerosis by modifying risk factors, such as healthy eating, exercise and avoidance of smoking.
Cardiovascular disease is today the largest single contributor to global mortality. A major challenge in human health over the next 50 years is to reduce the impact of chronic diseases. The health benefits of a diet rich in fruits, vegetables and legumes have been well recognized. Poor compliance to dietary recommendations, unhealthy lifestyle and mismanagement of cardiovascular emergencies reflect the dearth of awareness among the community. This book provides data on the nutritional, cardiovascular and biochemical profile of adults living with cardiovascular disease in the ‘Temple Town’ of Tamil Nadu, Madurai with lucid and interesting illustrations. An attempt has been made to associate these factors along with their critical energy balance with cardiovascular disease. Specific focus has also been on the occurrence of various metabolic syndrome components and cardiovascular disease. This book can adorn the bookshelf of academicians, researchers, nutritionists and scholars interested in clinical nutrition.
Atherosclerotic cardiovascular disease is the leading cause of death in the developed countries. Atherosclerosis begins in childhood and young adulthood. Physical activity reduces the risk of chronic disease, including diabetes, obesity and cardiovascular disease. Lower exercise levels have been associated with the incidence of coronary heart disease and stroke among youngs. Despite active lifestyles having an array of positive health and social benefits for young people, children today have fewer opportunities to be active in a safe and independent manner, especially in large cities. Adolescents also have become increasingly sedentary with a decrease in physical activity and an increase in sedentary behaviour over the past decades. Students spend large amounts of time in school and there is a a great potential for increasing their level of physical activity through school-based lesson of physical education. Increasing the levels of physical education in schools has been perceived as one way of getting young people involved in physical activity. There is an urgent need through the physical education lessons in school environment, establishing long-term lifestyle patterns.
Non-communicable diseases like coronary heart diseases are leading cause of morbidity and deaths in world. However, social determinants are distant determinants of health in terms of causation of diseases. This book is trying to explain how Social determinants are linked with the chronic diseases like myocardial infarction. Social determinants are not sufficient for causation of diseases. However, there is still a need to realize that these determinants are integral part of web of causation of diseases especially non-communicable diseases. This book aims to explore possible relationship between social determinants like socioeconomic status, smoking, stress and social support with coronary heart diseases in Mumbai, India. This study was carried out using quantitative case-control study design. The determinants like stress and smoking were important factors for acute myocardial infarction. This study helps in re-establishing direct as well as indirect relationship between social determinants like Socioeconomic status, smoking behaviour, social support and stress with the myocardial infarction.
Cardiovascular diseases are leading causes of death worldwide. Many efforts have been paid on understanding the underlying mechanisms and causes. However, identifying their risk factors and individual impacts on the diseases onset and progression might be the most effective ways, since specific solutions and treatments can be applied. Survival analysis is a statistical method and approach to identify potential factors and also their effects. Furthermore, it provides the power to predict when cardiovascular diseases might occur given those potential risk factors. This book introduces theories and methods of survival analysis, and also offers some mathematical deductions for conclusions. Therefore, it can be used as a reference book for senior undergraduates and graduates who are interested in the field. In addition, it also describes detail procedures for analysis.
Cardiovascular disease is one of the leading causes of death in the world and the number of patients increases worldwide. To investigate the cardiovascular disease in early stage, reliable model predictions are required. In computational cardiovascular models parameters are one of the major sources of uncertainty, which make the models unreliable and less predictive. In order to achieve predictive models that allow the investigations of the cardiovascular diseases, sensitivity analysis (SA) can be used to quantify and reduce the output uncertainty caused by model parameters.
Medical survey and studies highlights cardiovascular diseases as the prime cause for the loss of human lives. Overall impact of the cardiovascular diseases results in sublime demands for attention towards the objective of having early, quick and reliable identification of the symptoms. The advances in the field of technology have offered a platform over which one of the biggest challenges of the medical sciences can be analyzed for better solutions. The electrocardiogram (ECG), used for pre-diagnosis of the cardiovascular diseases, signifies the scope of technology and its involvement in medical sciences. For the measurement or understanding of electrical impulses and their activity in the heart ECG can be used. Electrocardiogram will be effectively used for non evasive detection of the vas diseases.This project avails the capability of Artificial Neural Network Techniques or ANN to analyze information of the patient records suffering from cardiovascular diseases & draws classification, that whether the patient is suffering from arrhythmia or not.
Cardiovascular diseases or heart disease or are the class of diseases that involve the heart or blood vessels. This book was designed to provide adequate knowledge on the subject of cardiovascular diseases for the students of pharmacy and medicine faculty. This book consists of pathophysiology and treatment of hypertension, congestive cardiac failure (CCF), angina pectoris and arrhythmia along with Hypolipidemic and blood coagulation, anticoagulants, thrombolytic and antiplatelet drugs. The content of the book has been prepared such that a student can understand not only the mechanism of action, pharmacological effects and therapeutic uses of drugs but also the pathophysiology of CVD. Most countries face high and increasing rates of cardiovascular disease. A large histological study showed vascular injury accumulates from adolescence, making primary prevention efforts necessary from childhood. By the time that heart problems are detected, the underlying cause is usually quite advanced, having progressed for decades. There is therefore increased emphasis on preventing atherosclerosis by modifying risk factors, such as healthy eating, exercise and avoidance of smoking.