A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.
The practical guide to investing in emerging markets Though potentially risky, investing in emerging markets can offer extremely attractive returns. Opportunities in Emerging Markets offers practical advice for investors based on the real life experiences—both positive and negative—of practitioners, pioneer investors, and local heroes with experience in frontier markets. Exploring how every developing market has its own unique regional cultures and social structures that change the way investors invest, and must be understood in order to make wise investments, the book combines standard approaches to investing with the exigencies of frontier markets to create an invaluable framework for success. A collection of useful ideas that investors—institutions, general partners, limited partners, or shareholders—can draw upon when investing money in emerging markets, the book includes essential information on one of the most attractive opportunities for beating traditional markets and investments. If access, downside, and predictability can be managed, there's a great deal of money to be made in emerging markets, and this book shows how. Both investors and investment managers need to understand fundamental success factors, real framework conditions, and hidden pitfall and in Opportunities in Emerging Markets, author Gordian Gaeta analyses these intricacies in depth. Gives investors of all kinds the information they need to succeed in emerging markets Incorporates real life experiences—both good and bad—to help readers avoid common mistakes and maximize their returns Includes interviews with Mark Mobius, Jim Rogers, Marc Faber, and other leading names in the emerging markets sector For those traders brave enough to engage in high-risk/high-return investing, Opportunities in Emerging Markets is an excellent overview of the world's toughest frontier markets and how to conquer them. Featuring interviews with some of the top investors in the field, this is the definitive guide to the perils and pitfalls of investing in these highly volatile markets.
Emerging markets are big news. But after the financial crisis, what does the future really hold for them? And what does this future mean for global business? George Magnus, one of the world's most respected economic analysts, is your guide through the challenges and opportunities for emerging markets and those doing business in them. This magisterial book looks in detail at China and India – the big players – and also less hyped but crucial markets, including Eastern European countries and Turkey. Magnus takes in his sweep everything from commodity prices to climate change, and from comparative advantage to demographic to provide a compelling analysis of what the future might look like – not just for emerging markets, but for investors, businesses and economies everywhere. Uprising is a must-read for anyone who cares about the future of the global economy.
The fifth installment of the Fisher Investments On series is a comprehensive guide to understanding and analyzing investment opportunities within emerging markets. Growing in relative importance in recent years, emerging markets offer dynamic and unique opportunities. Fisher Investments on Emerging Markets can benefit both new and seasoned investors, covering everything from regional basics to country-specific insights to practical investing tactics, including common pitfalls to avoid. This book begins with an overview of emerging markets, followed by a historical narrative of the major emerging market regions—with emphasis on the economic, political, and sentiment drivers that help shape the investing landscape. Discusses regional, and even country-specific, drivers. Examines the major regions, including Russia, China, Latin America, and Asia. Addresses the challenges unique to emerging and developing regions, and some common pitfalls to avoid. Delves into top-down investment methodology as well as individual security analysis. Outlines a five-step process to help differentiate firms in emerging markets—designed to help you identify ones with the greatest probability of outperforming Provides investment strategies for a variety of market environments Filled with in-depth insights and expert advice, Fisher Investments on Emerging Markets provides a framework for understanding emerging markets. With this book as your guide, you can quickly gain a global perspective on emerging markets and discover strategies to help achieve your investing goals.
Accelerating globalization of world markets and increasing interdependence of the economies of the world has made policy-making very complex, especially in the United States. One of the most debated subjects in recent years has been whether the U.S. is capable of simultaneously dealing with serious domestic challenges and economic challenges from the rest of the world. It is becoming more important for the generalist in economics, political science, business, and other areas to understand the issues confronting the American economy in relation to rapid global economic change.
A comprehensive guide to success in the changing HR leadership role THREE is the definitive guidebook for thriving in the ever-changing role of HR leadership. Itis written for high potential HR emerging executives who want to accelerate their effectiveness and business impact, and for the bosses, peers, colleagues, friends, coaches, mentors, and teachers who want to assist them in doing so. Centered around three critical and complementary aspects of the role, this book explores leadership philosophy, HR's evolving role in today's organizations, and the future of HR and effective organizations to help emerging HR leaders find and establish their place in the field. The interplay between leadership and HR competencies is clearly laid out, and lessons learned from CHROs and other HR leaders, as well as academic thought leaders, form the basis of authoritative coverage of crucial components of effective HR leadership, now and in the future. The discussion simplifies the relationship between business strategy and human capital strategy; balances the «what,» «who,» and «when» of HR leader development, and explores the themes, trends, and implications emerging in the HR field. You'll learn how to lead change, master the art of the question, build leadership and talent, create a performance culture, understand Boardroom dynamics, and learn tips and techniques from over one hundred of the very best HR leaders. The book begins with a comprehensive self-assessment, and each chapter ends with a self-assessment specific to that chapter. Also, a wealth of tools and checklists are included to help you start immediately applying what you've learned. HR leaders are under more pressure than ever to deliver high quality people-related solutions quickly and effectively, but they often don't have the broad foundational experience and perspective to effectively do so. This book provides the solution in the form of comprehensive examination and practical implementation of the critical components of the HR leadership role. Develop a personal leadership philosophy, and behaviors for success Embody the changing HR role to make people and organizations more effective Ask the right questions and effectively engage other leaders Create a performance-driven culture and anticipate critical resistance points Anticipate and prepare for the future of work, organizations, and HR to ensure you remain relevant Today's organizations demand a broader array of cross-functional and cross-organizational perspectives to address complex multi-dimensional challenges and orchestrate practical solutions. THREE is the emerging HR leader's guide to acquiring the mindset and skillset required for success.
A comprehensive guide focusing on the valuation issues for emerging markets Valuation of Companies in Emerging Economies takes a practical, step-by-step approach to valuing both public and closely held companies in emerging economies for merger or acquisition purposes. These extremely volatile markets present their own special set of challenges, which often differ from country to country. The author provides real world, best valuation practices in both developed and emerging markets and offers links to relevant Internet resources to provide CEOs, CFOs, venture capitalists, and financial analysts with the information they need to accurately value companies around the world. Luis E. Pereiro (Buenos Aires, Argentina) is a consultant who has steered several strategic change projects in multinational corporations such as Bank of America, Union Carbide, and Nissho Iwai. He is Interim Dean of the Universidad Tocuato Di Tella, Buenos Aires, as well as Director of its MBA program and Director of the Center for Entrepreneurship and Business Venturing. His numerous articles have appeared in many prestigious business journals and books. Over the years, financial professionals around the world have looked to the Wiley Finance series and its wide array of bestselling books for the knowledge, insights, and techniques that are essential to success in financial markets. As the pace of change in financial markets and instruments quickens, Wiley Finance continues to respond. With critically acclaimed books by leading thinkers on value investing, risk management, asset allocation, and many other critical subjects, the Wiley Finance series provides the financial community with information they want. Written to provide professionals and individuals with the most current thinking from the best minds in the industry, it is no wonder that the Wiley Finance series is the first and last stop for financial professionals looking to increase their financial expertise.
In this book, the author addresses technologies that are being used in emerging cellular markets. These include GSM/EGPRS and CDMA which are being deployed at a rapid pace, while technologies such as UMTS (3G)/ HSPA (3.5G) which have started to find a place in these high growth markets, are also considered. The book examines other technologies including LTE (3.9G) which have already moved out of research labs into the commercial world. 2G-CDMA is widely used, while further developments, e.g. CDMA2000 are also finding acceptance in the commercial arena. IMS/Convergence is increasingly popular all over the world; UMA, which is deployed mostly in North America; and DVB which is gaining worldwide popularity, especially in South Asia, are all reviewed. Each chapter discusses a different technology and is structured into three parts. The technology is examined at an overview level, first explaining what the technology is and then considering the technical features of the technology. The chapter concludes by looking at the planning/implementation aspects of the technology. Key Features: Useful for all cellular industry professionals as provides an overview of the currently deployed technologies in mass scale, and the forthcoming technologies that are expected to make an impact in the future, such as 4th Generation Cellular Networks. One of the first books on the market to encompass all the major cellular technologies, as well as considering the design and implementation perspective. Wireless Technology will play a key role in uplifting the economies of the Emerging countries globally. Ashok Chandra, Wireless Advisor to Govt. of India
For more than a decade, emerging markets have proved one of the most exciting areas of investment, but the sector has not been without its dangers. Private and professional investors alike have continuously been attracted by the promise of riches on offer from countries such as China, India, Brazil and Russia but, as often as not, have been left with their fingers burnt. Investing in Emerging Markets: The BRIC Economies and Beyond tempers the undoubted causes for emerging market optimism with a healthy dose of reality, illustrating how for every argument in favour of investing in the sector there are one or more reasons to tread very carefully indeed. In the wake of the credit crunch and ensuing market turmoil, it also analyses where the emerging markets now fit within the global investment landscape. With the economies of the US, Europe and Japan hit by an economic crisis very much of their own making, has the credibility gap between developed and developing markets narrowed? Has the playing field become more level? Investing in Emerging Markets: The BRIC Economies and Beyond offers a fresh, clear-eyed and objective look at an area that can only grow in importance over the next decade. It balances a realistic appraisal of the opportunities on offer from the emerging markets with a pragmatic assessment of the potential pitfalls facing investors, in the process providing an accessible introduction to newcomers and more experienced investors with a valuable and compact point of reference.
This book provides a comprehensive view of the emerging standards for VoIP emergency calling from an International perspective In this book, the authors provide a treatment of the VoIP emergency calling process that is both comprehensive, looking at all aspects of emergency calling, and practical, providing technical details on how such functions can be implemented. In addition, the authors describe the standardization efforts of the Internet Engineering Task Force who are currently working to improve the situation for VoIP emergency calls. The book provides an overview of emergency calling with a particular focus on the ECRIT emergency calling architecture, and discusses considerations related to implementation, deployment, and regulation of next-generation emergency calling. It also takes a look at practical aspects of emergency calling, with a set of exercises to help the reader get familiar with the technologies involved. Key Features: Comprehensive view of emerging standards for VoIP emergency calling from an international perspective Practical guides for implementing the core of the emergency calling architecture Architectural, practical, and regulatory perspectives Written by experts working on the development of emergency calling architectures and its implementation Includes an accompanying website with open-source software packages (http://www.voip-sos.net/) This book will be an invaluable resource for product managers and developers, equipment vendors, network operators, emergency service providers, and telecommunications regulators. Industry professionals interested in standards compliance will also find this book of interest.
The information you need to invest in emerging markets, in one Little Book The world's economies are in a state of flux. The traditional dominance of the G7 countries is being challenged by emerging market nations like Brazil and India, and while investment opportunities in these countries abound, the risks can be extremely high. In this Little Book, Mark Mobius, an internationally-renowned expert on emerging market funds, explains the ins and outs of emerging market investment, providing practical guidance on picking industries and companies likely to win, and explaining why policies and regulations matter as much as balance sheets, how to recognize global contenders, techniques for managing risk, and how to get out at the right time. The emerging markets are expected to be a key driver of future global economic growth, and with The Little Book of Emerging Markets in hand, you have everything you need to take full advantage of these incredible opportunities. Explains how to pick the industries and companies mostly likely to boom, why policies and regulation are key to making intelligent investment decisions, how to recognize genuine opportunities, and much more Includes invaluable techniques for managing your risk Shows you how to get your money in and out of emerging markets without being burned The Little Book of Emerging Markets is the perfect little guide to the world's most exciting investment opportunities.
BRICs and Beyond is an international business executive text written especially for executive and MBA students. It is based on extensive consulting in emerging economies and several years of experience teaching executive MBA courses around the globe. The author has continually faced the problem that the available textbooks for teaching international business focused almost exclusively on examples of Western multinationals for case illustrations. In the process of preparing cases nearer to the emerging market she worked in, the author realized that the often fascinating, frequently insightful and always different approach to business illustrated by these cases should be required reading for MBA students in typical Western environments too. With its wide range of current case illustrations and concise summaries this is a new-generation text that will welcome today's MBA student to the wider world of 21st century international business. «. . . this book is needed not only because it looks at business from the BRICs points of view; it also looks at business from the point of view of tomorrow's business leaders and the challenges that they will have to cope with.» –Professor Jonathan Gosling, Centre for Leadership Studies, and co-founder, The One-Planet MBA, the University of Exeter, UK «. . . Stephanie Jones advises Western businesses on doing business in emerging economies in a refreshingly straightforward manner, integrating in a novel way her three decades of global, practical experience with the daily barrage of reporting on the BRICs–distilling from these many lessons and principles. . .» –Extracted from the Foreword, by Professor Wim Naudé, Director of Research, Maastricht School of Management
The last quarter of a century has seen an unprecedented wave of democratization around the globe. In these transitions from authoritarian rule to a more democratic order, the media have played a key role both by facilitating, but frequently also inhibiting, democratic practices to take root. This book provides an accessible and systematic introduction to the media in transitional democracies. It analyses the problems that occur when transforming the media into independent institutions that are able to inform citizens and hold governments to account. The book covers the following topics: normative conceptions of media and democracy; the role of the past in the transition process; the internet as a new space for democratic change; the persistence of political interference in emerging democracies; the interlocking power of media markets and political ownership; the challenges to journalistic professionalism in post-authoritarian contexts; the role of the media in divided societies; The book takes a global view by exploring the interplay of political and media transitions in different pathways of democratization that have taken place in Eastern Europe, Latin America, Africa and Asia. It will be of interest to advanced students and scholars who want a better understanding of the media outside established Western democracies. The book will also be of great value to policymakers and activists who are involved in strengthening the media in transitional democracies.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
Featuring a collection of original chapters by leading and emerging scholars, The Wiley-Blackwell Companion to Sociology presents a comprehensive and balanced overview of the major topics and emerging trends in the discipline of sociology today. Features original chapters contributed by an international cast of leading and emerging sociology scholars Represents the most innovative and 'state-of-the-art' thinking about the discipline Includes a general introduction and section introductions with chapters summaries by the editor