This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes.
This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
Encompasses the latest advances in the field. New series editor, Daniel Purich, is a well-known biochemist and enzymologist.
This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamentals right up to the latest, most advanced levels of study.
A comprehensive guide to empirical and theoretical research advances in culture and biology interplay Culture and biology are considered as two domains of equal importance and constant coevolution, although they have traditionally been studied in isolation. The Handbook of Culture and Biology is a comprehensive resource that focuses on theory and research in culture and biology interplay. This emerging field centers on how these two processes have evolved together, how culture, biology, and environment influence each other, and how they shape behavior, cognition, and development among humans and animals across multiple levels, types, timeframes, and domains of analysis. The text provides an overview of current empirical and theoretical advances in culture and biology interplay research through the work of some of the most influential scholars in the field. Harnessing insights from a range of disciplines (e.g., biology, neuroscience, primatology, psychology) and research methods (experiments, genetic epidemiology, naturalistic observations, neuroimaging), it explores diverse topics including animal culture, cultural genomics, and neurobiology of cultural experiences. The authors also advance the field by discussing key challenges and limitations in current research. The Handbook of Culture and Biology is an important resource that: Gathers related research areas into the single, cohesive field of culture and biology interplay Offers a unique and comprehensive collection from leading and influential scholars Contains information from a wide range of disciplines and research methods Introduces well-validated and coherently articulated conceptual frameworks Written for scholars in the field, this handbook brings together related areas of research and theory that have traditionally been disjointed into the single, cohesive field of culture and biology interplay.
A comprehensive overview of high-performance pattern recognition techniques and approaches to Computational Molecular Biology This book surveys the developments of techniques and approaches on pattern recognition related to Computational Molecular Biology. Providing a broad coverage of the field, the authors cover fundamental and technical information on these techniques and approaches, as well as discussing their related problems. The text consists of twenty nine chapters, organized into seven parts: Pattern Recognition in Sequences, Pattern Recognition in Secondary Structures, Pattern Recognition in Tertiary Structures, Pattern Recognition in Quaternary Structures, Pattern Recognition in Microarrays, Pattern Recognition in Phylogenetic Trees, and Pattern Recognition in Biological Networks. Surveys the development of techniques and approaches on pattern recognition in biomolecular data Discusses pattern recognition in primary, secondary, tertiary and quaternary structures, as well as microarrays, phylogenetic trees and biological networks Includes case studies and examples to further illustrate the concepts discussed in the book Pattern Recognition in Computational Molecular Biology: Techniques and Approaches is a reference for practitioners and professional researches in Computer Science, Life Science, and Mathematics. This book also serves as a supplementary reading for graduate students and young researches interested in Computational Molecular Biology.
The classic and authoritative textbook, Molecular Mechanisms of Photosynthesis,is now fully revised and updated in this much-anticipated second edition. Whilst retaining the first edition’s clear writing style and accessible description of this complex process, updates now include cutting-edge applications of photosynthesis, such as to bioenergy and artificial photosynthesis as well as new analytical techniques. Written by a leading authority in photosynthesis research, this new edition is presented in full color with clear, student-friendly illustrations. An interdisciplinary approach to photosynthesis is taken, with coverage including the basic principles of energy storage, the history and early development of photosynthesis, electron transfer pathways, genetics and evolution. A comprehensive appendix, containing an introduction to the basic chemical and physical principles involved in photosynthesis, is also included. Molecular Mechanisms of Photosynthesis,second edition, is an indispensable text for all students of plant biology, bioenergy, and molecular biology, in addition to researchers in these and related fields looking for an accessible introduction to this vital and integral process to life on earth. stresses an interdisciplinary approach emphasizes recent advances in molecular structures and mechanisms includes the latest insights and research on structural information, improved techniques as well as advances in biochemical and genetic methods comprehensive appendix, which includes a detailed introduction to the physical basis of photosynthesis, including thermodynamics, kinetics, and spectroscopy associated website with downloadable figures as powerpoint slides for teaching
Recent years have seen extensive research in the molecular underpinnings of symbiotic plant-fungal interactions. Molecular Mycorrhizal Symbiosis is a timely collection of work that will bridge the gap between molecular biology, fungal genomics, and ecology. A more profound understanding of mycorrhizal symbiosis will have broad-ranging impacts on the fields of plant biology, mycology, crop science, and ecology. Molecular Mycorrhizal Symbiosis will open with introductory chapters on the biology, structure and phylogeny of the major types of mycorrhizal symbioses. Chapters then review different molecular mechanisms driving the development and functioning of mycorrhizal systems and molecular analysis of mycorrhizal populations and communities. The book closes with chapters that provide an overall synthesis of field and provide perspectives for future research. Authoritative and timely, Molecular Mycorrhizal Symbiosis, will be an essential reference from those working in plant and fungal biology.
In recent years, considerable progress has been made in understanding the vasculitic diseases, largely due to the introduction of effective treatments for diseases that were once uniformly fatal, the conduct of structured clinical studies, and advances in immunology and molecular biology. Despite these achievements, the vasculitic diseases continue to be associated with morbidity and mortality from chronic organ damage, relapses, and the side effects of treatment. Investigations into the mechanisms of vascular inflammation may lead to a better comprehension of the pathogenesis of vasculitic diseases and to treatment that is more effective and less toxic. These areas of promising research, together with current knowledge about the vasculitic diseases, are extensively examined in this new edition, which is designed to provide a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.
A newly revised edition of the standard reference for the field today—updated with new terms, major discoveries, significant scientists, and illustrations Developmental biology is the study of the mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, and genetic levels. The discipline has gained prominence in part due to new interdisciplinary approaches and advances in technology, which have led to the rapid emergence of new concepts and words. The Dictionary of Developmental Biology and Embryology, Second Edition is the first comprehensive reference focused on the field's terms, research, history, and people. This authoritative A-to-Z resource covers classical morphological and cytological terms along with those from modern genetics and molecular biology. Extensively cross-referenced, the Dictionary includes definitions of terms, explanations of concepts, and biographies of historical figures. Comparative aspects are described in order to provide a sense of the evolution of structures, and topics range from fundamental terminology, germ layers, and induction to RNAi, evo-devo, stem cell differentiation, and more. Readers will find such features of embryology and developmental biology as: Vertebrates Invertebrates Plants Developmental genetics Evolutionary developmental biology Molecular developmental biology Medical embryology The author's premium on accessibility allows readers at all levels to enhance their vocabulary in their field and understand terminology beyond their specific focus. Researchers and students in developmental biology, cell biology, developmental genetics, and embryology will find the dictionary to be a vital resource.
Annual Plant Reviews, Volume 8 In the last few years, the new analytical tools associated with molecular biology, biochemistry, spectroscopy, microscopy, immunology, genomics and proteomics have been employed to investigate plant cell wall structure and function, providing a degree of resolution that was, until recently, unattainable. This has resulted in a growing awareness of the critical role of plant cell walls in a broad range of developmental events, adding strength and diversity to cell wall-related scientific research. This volume provides an overview of our current understanding of plant cell walls, drawing on the recent advances of plant molecular biology. It incorporates the identification of a rapidly growing number of genes and the proteins responsible for plant wall synthesis, restructuring, degradation and wall-associated signal transduction. The book bridges the biochemistry-oriented cell wall literature and the new technology-driven approaches. This is a book for academic and industrial researchers in plant cell biology, biochemistry, developmental biology, genetics and molecular biology.
A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspectsof molecular discovery, as well as the thought processes behind experimental approaches. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
A comprehensive overview of current empirical valence bond (EVB) theory and applications, one of the most powerful tools for studying chemical processes in the condensed phase and in enzymes. Discusses the application of EVB models to a broad range of molecular systems of chemical and biological interest, including reaction dynamics, design of artificial catalysts, and the study of complex biological problems Edited by a rising star in the field of computational enzymology Foreword by Nobel laureate Arieh Warshel, who first developed the EVB approach
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Cell and Molecular Biology and Imaging of Stem Cells features original and review articles written by experts who have made significant contributions to stem cell biology and imaging. Chapters cover a broad spectrum of aspects of the field, including Stem cells from the Amniotic Fluid and Placenta, Biomaterials as Artificial Niches for Pluripotent Stem Cell Engineering, Low-Intensity Ultrasound in Stem Cells and Tissue Engineering, Mammalian Neo-Oogenesis from Ovarian Stem Cells, Oct4-EGFP Transgenic Pigs as a New Tool for Visualization of Pluripotent and Reprogrammed Cells, Regulation of Adult Intestinal Stem Cells, Stem Cell Therapy for Veterinary Orthopedic Lesions, Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases, Hair Follicle Stem Cells, The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases, Mitochondrial Differentiation in Early Embryo Cells and Pluripotent Stem Cells, and The Role of Centrosomes in Cancer Stem Cell Functions. Cell and Molecular Biology and Imaging of Stem Cells addresses a wide variety of cell and molecular topics in unprecedented detail, and is a must-read for graduate students and academic and industry professionals in the expanding field of stem cell biology. Reviews new imaging tools and markers for cell and molecular imaging in stem cell biology. Covers novel aspects of stem cell imaging in reproductive biology and stem cell niches Includes chapters on the developing area of centrosome biology as it applies to embryonic and adult stem differentiation