Gerald is careful. Piggie is not. Piggie cannot help smiling. Gerald can. Gerald worries so that Piggie does not have to. Gerald and Piggie are best friends. In I Will Surprise My Friend!, Gerald and Piggie want to play a game and surprise each other, but the best surprise is the one they least expect.
The incidence of cancer, diabetes mellitus, cardiovascular and some other diseases continues to increase and there are still no sufficiently successive healing and preventive strategies. Insulin-like growth factors (IGFs) play important roles during entire life and, depending on the biochemical pathway in which they are involved, they may be regarded as growth factors, hormones or cytokines. IGFs exert their functions after binding to specific receptors and their availability is regulated by IGF-binding proteins. Altered activity in the IGF signaling pathways is connected with diseases, but data are controversial as both beneficial and harmful effects of IGFs were recorded. Traditional approaches to study biochemical pathways, mostly based on the synthesis and clearance rates, are not sufficient. Post-translational protein modifications and associations with other biomolecules may represent an intermediate level of control, which deserves more attention. This book provides an overview of the post-translational events which affect the IGF system, offering experimental data to document structural and functional changes which, as a final consequence, have altered IGF activity.
Gerald is careful. Piggie is not. Piggie cannot help smiling. Gerald can. Gerald worries so that Piggie does not have to. Gerald and Piggie are best friends. In Are You Ready to Play Outside?, Piggie can't wait to go and play in the sunshine. But will a rainy day ruin all the fun?
According to WHO 2012 report 347 million people worldwide have Diabetes. Diabetes mellitus is a serious pathological condition responsible for major healthcare problems worldwide and costing billions of dollars annually. Conventional insulin therapies involve multiple daily subcutaneous injections having many challenges. Hence novel approaches for insulin delivery are being explored. A variety of alternative routes/methods have been investigated to improve systemic insulin delivery. Peroral and nasal insulin administrations have demonstrated good potential for the treatment of diabetes. In addition, pulmonary, buccal, and ocular insulin administration have been shown to decrease serum glucose concentrations. Other methods that have been investigated for their potential in systemic insulin delivery include rectal, vaginal, and uterine routes. This book is helpful to the medical and paramedical students and also researchers who work for the development of novel insulin drug delivery systems and devices.
Gerald is careful. Piggie is not. Piggie cannot help smiling. Gerald can. Gerald worries so that Piggie does not have to. Gerald and Piggie are best friends. In Watch Me Throw the Ball!, Gerald is determined to teach Piggie that ball-throwing is a serious business ... but Piggie is just as determined to have serious fun.