Emerging Infectious Diseases offers an introduction to emerging and reemerging infectious disease, focusing on significant illnesses found in various regions of the world. Many of these diseases strike tropical regions or developing countries with particular virulence, others are found in temperate or developed areas, and still other microbes and infections are more indiscriminate. This volume includes information on the underlying mechanisms of microbial emergence, the technology used to detect them, and the strategies available to contain them. The author describes the diseases and their causative agents that are major factors in the health of populations the world over. The book contains up-to-date selections from infectious disease journals as well as information from the Centers for Disease Control and Prevention, the World Health Organization, MedLine Plus, and the American Society for Microbiology. Perfect for students or those new to the field, the book contains Summary Overviews (thumbnail sketches of the basic information about the microbe and the associated disease under examination), Review Questions (testing students' knowledge of the material), and Topics for Further Discussion (encouraging a wider conversation on the implications of the disease and challenging students to think creatively to develop new solutions). This important volume provides broad coverage of a variety of emerging infectious diseases, of which most are directly important to health practitioners in the United States.
Presents the latest research and applications for a new, promising approach to fighting infectious diseases Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications. The book begins with four chapters that review the potential applications, possible advantages, and phylogeny of enzybiotics. Next, the book explores: A new approach to controlling infections using Gram-negative bacteria Bacteriophage holins and their membrane-disrupting activity Anti-staphylococcal lytic enzymes Membrane-targeted enzybiotics Design of phage cocktails for therapy from a host-range point of view Novel methods to identify new enzybiotics Genetically modified phages that deliver suicidal genes to target bacteria The authors, all active enzybiotics researchers, offer a variety of perspectives, the benefit of their own hands-on investigations, as well as a thorough review and analysis of the current literature. As more and more bacteria become resistant to antibiotics, the development of new disease-fighting agents has become essential. This book demonstrates the full potential of the emerging field of enzybiotics to control infectious diseases. Moreover, it will serve as a springboard for new research and the development of new therapeutics.
Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
As a foundation to a successful career in clinical medicine every physician needs to be able to establish a good rapport with the patient, accurately record all presenting symptoms and signs, and finally make an accurate diagnosis. "Internal diseases propedeutics" offers a thorough grounding in the principles of the physical examination and provides a detailed account of the symptoms and signs of diseases affecting the body systems. This textbook includes chapters on diagnosis of pulmonary, cardiovascular, digestive, genitourinary, nutritional, endocrine disorders and diseases of blood. The book covers both basic clinical skills, and high technology investigations and interventions that are utilised today by the physician. The "Internal diseases propedeutics" ensures that it will remain an invaluable source of information for all medical students and junior doctors of all specialities in their early years of clinical practice.
Keep your family safe from tick-borne infections With millions around the world infected-and millions more at risk-Lyme and other tick-related disorders are today's fastest-growing infectious diseases. And while there has been much progress in combating these illnesses, we are a long way from eliminating them. Early treatment is crucial-and there's no better way to get informed and be prepared to deal with these diseases than to read this book. This comprehensive guide tells you everything you need to know to protect yourself and your family from the pain of Lyme, including vital information about the new Lyme disease vaccines. Written by Lyme disease pioneer Karen Vanderhoof-Forschner-cofounder of the Lyme Disease Foundation and a Lyme sufferer herself-this updated and expanded edition provides the latest on the multiple diseases that can be transmitted in a single tick bite and the symptoms that indicate you've been infected. In easy-to-understand language, the author discusses the often controversial issues of diagnosis and treatment of Lyme while reviewing the other tick-borne diseases in North America, such as Rocky Mountain Spotted Fever, tularemia, the emerging ehrlichioses, and some that are considered potential biowarfare agents. She offers expert advice on: * Protecting yourself from disease-carrying ticks-and what to do if you find one on your skin * Obtaining the best medical treatment * Accessing online information on vaccines, repellents, and the latest research * Finding self-help and support organizations, state medical complaint boards, products, and related services * Starting a school or business prevention program
This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.
Clinical Canine and Feline Respiratory Medicine provides reliable information on the diagnosis and management of respiratory disease in a user-friendly format. With an emphasis on the features of the history and physical examination that aid in efficient diagnostic planning, the book is an accessible, readable resource for optimizing treatment of patients with diseases of the respiratory tract. Offering comprehensive, accessible coverage of respiratory disorders, Clinical Canine and Feline Respiratory Medicine is a useful practice guide and study aid for general practitioners and veterinary students. Beginning with introductory chapters on the localization of disease, diagnostics, and therapeutics, the heart of the book focuses on the full range of respiratory diseases, including nasal disorders, diseases of airways, parenchymal diseases, pleural and mediastinal diseases, and vascular disorders. Each chapter takes a common format with diseases subdivided by etiology into structural, infectious, inflammatory, and neoplastic disorders. Clinical Canine and Feline Respiratory Medicine is a useful tool for students and practitioners engaged in studying, diagnosing, and treating respiratory disease.
A quick, concise reference to pathogenic microorganisms and the diseases they cause, this book is divided into specific groups of pathogenic microorganisms including bacteria, protozoa, fungi, viruses, and prions. It lists important pathogenic taxa in each group, covering their natural habitats, the diseases they cause, microbiological highlights, laboratory diagnosis, and measures of prevention and control, including availability of vaccines and effective therapeutic agents. All healthcare professionals and public health workers will benefit from having this reliable source of information at their fingertips.
Small Animal Pathology for Veterinary Technicians fosters an understanding of small animal diseases, relating pathology information to the responsibilities of technicians in the clinical setting. Beginning with the technician’s role in pathology, terminology, and the process of diagnosis, chapters then cover diseases organized by system. From reproductive, endocrine, and eye disease to urinary tract and infectious diseases, the book offers in-depth information on a wide range of commonly presented diseases, providing technicians with practical information linked to their daily tasks. Each body system includes a brief review of anatomy and function, full-color pictures, and tip boxes to help emphasize important issues. A companion website offers images from the book, review questions, and case studies illustrating the process of handling the patient at www.wiley.com/go/johnsonvettechpath. Veterinary technician students and veterinary technicians in practice will find this a valuable resource to understanding disease and the process of diagnosis.
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.
An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.
Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
Prevention is the first line of defence in the fight against infection. As antibiotics and other antimicrobials encounter increasing reports of microbial resistance, the field of decontamination science is undergoing a major revival. A Practical Guide to Decontamination in Healthcare is a comprehensive training manual, providing practical guidance on all aspects of decontamination including: microbiology and infection control; regulations and standards; containment, transportation, handling, cleaning, disinfection and sterilization of patient used devices; surgical instrumentation; endoscopes; and quality management systems. Written by highly experienced professionals, A Practical Guide to Decontaminationin Healthcare comprises a systematic review of decontamination methods, with uses and advantages outlined for each. Up-to-date regulations, standards and guidelines are incorporated throughout, to better equip healthcare professionals with the information they need to meet the technical and operational challenges of medical decontamination. A Practical Guide to Decontaminationin Healthcare is an important new volume on state-of-the-art decontamination processes and a key reference source for all healthcare professionals working in infectious diseases, infection control/prevention and decontamination services.
This comprehensive and concise presentation of genetic factors in cardiovascular disease and their response to therapy consolidates knowledge of this high-interest and emerging topic. Covering broad areas of contemporary genomic medicine and specific cardiovascular diseases, this book is a must for anyone seeking to better understand this rapidly developing field.