Anxiety is an exaggerated feeling of apprehension, uncertainty, and fear. It is an unpleasant state of tension with an anticipation of imminent danger. Benzodiazepines are still the most frequently used drugs for the treatment of generalized anxiety disorder despite their undesirable side effects such as muscle relaxation, sedation, physical dependence, memory disturbance, and interaction with other drugs. The present study was undertaken to evaluate the Standardization of Leaves, anxiolytic activity of Methanolic & Aqueous extract of Tribulus terrestris Linn. The anxiolytic activity was evaluated by Elevated plus Maze & Light Dark Model behavior models. The efficacy of the extract (200 mg/kg) was compared with the standard anxiolytic drugs Diazepam (2 mg/kg). The result showed that the extract significantly increased the number of entries and time spent in the open arm in the elevated plus maze. Both extracts showed significant anxiolytic activity. However Methanolic extract possessed more significant activity as compare to the aqueous extract in Elevated Plus Maze model and Light Dark model.
Diabetic nephropathy is a serious complication of diabetes in which elevated blood sugar levels eventually damage the kidneys. Nephropathy means disease or abnormality of the kidney. Diabetic nephropathy is also called diabetic kidney disease. Diabetic nephropathy is the kidney disease that occurs as a result of diabetes. It is a leading cause of kidney failure in Europe and the USA. After many years of diabetes the delicate filtering system in the kidney becomes destroyed, initially becoming leaky to large blood proteins such as albumin which are then lost in urine. This is more likely to occur if the blood sugar is poorly controlled. Herbal medication is the most commonly used alternative therapy for treatment of diabetes and its complication. Present treatment for diabetic nephropathy requires two drugs hypoglycemic and angiotensin converting enzyme inhibitor, from the above study Tribulus terrestris aqueous extract showed significant anti-diabetic as well as renoprotective effect by decreasing serum creatinine, blood urea nitrogen, urinary albumin and creatinine clearance.
Problems related to liver such as acute or chronic inflammation, toxin-/drug-induced hepatitis, cirrhosis and hepatitis are very common today due to our exposure to different environmental pollutants like chemicals, toxins, viruses etc. For centuries, many herbs have been used as natural medications for the prevention and/or treatment of liver diseases. Thus, the aim of the present study was to evaluate the role of Tribulus terrestris Linn. on acetaminophen-induced liver damage in rats. The rats were divided into five groups of 6 rats each for seven days oral administration. The methanolic extract of Tribulus terrestris L. produced significant hepatoprotective effects as evidenced by decreased serum enzyme activities, SGOT, SGPT, ALP, serum bilirubin, increased total protein. Histopathological architecture of the liver in test group was identical to the reference group. Based on our present findings, it can be concluded that Tribulus terrestris Linn. protects the liver from acetaminophen-induced hepatic damage by stabilizing effect on the plasma membrane as was reported in the case of Silymarin. Responsible leads for the present hepatoprotective studies are flavonoids.