Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.
A real-world guide to the production and manufacturing of biopharmaceuticals While much has been written about the science of biopharmaceuticals, there is a need for practical, up-to-date information on key issues at all stages of developing and manufacturing commercially viable biopharmaceutical drug products. This book helps fill the gap in the field, examining all areas of biopharmaceuticals manufacturing, from development and formulation to production and packaging. Written by a group of experts from industry and academia, the book focuses on real-world methods for maintaining product integrity throughout the commercialization process, clearly explaining the fundamentals and essential pathways for all development stages. Coverage includes: Research and early development phase–appropriate approaches for ensuring product stability Development of commercially viable formulations for liquid and lyophilized dosage forms Optimal storage, packaging, and shipping methods Case studies relating to therapeutic monoclonal antibodies, recombinant proteins, and plasma fractions Useful analysis of successful and failed products Formulation and Process Development Strategies for Manufacturing Biopharma-ceuticals is an essential resource for scientists and engineers in the pharmaceutical and biotech industries, for government and regulatory agencies, and for anyone with an interest in the latest developments in the field.
The definitive book on the neutralization of recombinant biopharmaceuticals Recombinant biopharmaceuticals are an important tool for treating a range of illnesses; however, their efficacy can be severely impaired by their immunogenicity. When introduced into the body, these pharmaceuticals can cause the immune system to produce anti-drug antibodies (ADAs) that neutralize their effects. The first and only book to cover neutralization in connection with biopharmaceuticals and the measurement and application of neutralizing antibodies in modern medicine at any real length, Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations offers a comprehensive and in-depth look at all the principal aspects of the detection and quantification of antibodies that are essential to understanding and responding to the challenges they present. Bringing together a large-scale review of neutralization and biopharmaceuticals and the ability to measure, detect, and apply antibodies to modern science and medicine with international regulatory perspectives, the expectations of regulatory authorities, and the strengths and weaknesses of various assays, the book describes several novel ideas for detecting ADAs. Designed to serve as a resource for biopharmaceutical drug development, the book provides biotechnology companies and pharmaceutical drug development specialists, as well as non-experts, with key insights into the design, optimization, and qualification of assays, the establishment of sampling strategies, the choice of appropriate assay end-points, and data analysis for the detection and quantification of neutralizing antibodies.
Aquaculture is an increasingly diverse industry with an ever-growing number of species cultured and production systems available to professionals. A basic understanding of production systems is vital to the successful practice of aquaculture. Published with the World Aquaculture Society, Aquaculture Production Systems captures the huge diversity of production systems used in the production of shellfish and finfish in one concise volume that allows the reader to better understand how aquaculture depends upon and interacts with its environment. The systems examined range from low input methods to super-intensive systems. Divided into five sections that each focus on a distinct family of systems, Aquaculture Production Systems serves as an excellent text to those just being introduced to aquaculture as well as being a valuable reference to well-established professionals seeking information on production methods.
Petroleum Production Engineering, A Computer-Assisted Approach provides handy guidelines to designing, analyzing and optimizing petroleum production systems. Broken into four parts, this book covers the full scope of petroleum production engineering, featuring stepwise calculations and computer-based spreadsheet programs. Part one contains discussions of petroleum production engineering fundamentals, empirical models for production decline analysis, and the performance of oil and natural gas wells. Part two presents principles of designing and selecting the main components of petroleum production systems including: well tubing, separation and dehydration systems, liquid pumps, gas compressors, and pipelines for oil and gas transportation. Part three introduces artificial lift methods, including sucker rod pumping systems, gas lift technology, electrical submersible pumps and other artificial lift systems. Part four is comprised of production enhancement techniques including, identifying well problems, designing acidizing jobs, guidelines to hydraulic fracturing and job evaluation techniques, and production optimization techniques.
Immunohistochemistry and immunocytochemistry are invaluable tools for the visualization of tissue and cellular antigens in diagnostic and biological research environments. The need to obtain accurate, reliable and reproducible results is paramount. It is with this fundamental aim in mind that we have compiled Immunohistochemistry: Essential Methods. We have achieved this by examining each aspect of immunochemistry in turn, with each chapter including detailed information regarding the subject matter in question. Each chapter is written by an expert in their field and includes protocols that are typically used in their own research. Subjects covered are, amongst others, antibodies and their production; selection of reporter labels; immunochemical staining methods and experimental design (both using single and multiple reporter labels); quality assurance; automated immunochemistry; confocal microscopy and electron microscopy. In addition, benefits and limitations of each approach are discussed within the chapters.
Oncology Book of 2011, British Medical Association's Medical Book Awards Awarded first prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.
A compilation of 76 articles from the ULLMANN's Encyclopedia of Industrial Chemistry, this three-volume handbook contains a wealth of information on the production and industrial use of more than 2,000 of the most important fine chemicals, from «Alcohols» to «Urea Derivatives». Chemical and physical characteristics, production processes and production figures, main uses, toxicology and safety information are all found here in one single resource.
The first comprehensive book to uniquely combine the three fields of systems engineering, operations/production systems, and multiple criteria decision making/optimization Systems engineering is the art and science of designing, engineering, and building complex systems—combining art, science, management, and engineering disciplines. Operations and Production Systems with Multiple Objectives covers all classical topics of operations and production systems as well as new topics not seen in any similiar textbooks before: small-scale design of cellular systems, large-scale design of complex systems, clustering, productivity and efficiency measurements, and energy systems. Filled with completely new perspectives, paradigms, and robust methods of solving classic and modern problems, the book includes numerous examples and sample spreadsheets for solving each problem, a solutions manual, and a book companion site complete with worked examples and supplemental articles. Operations and Production Systems with Multiple Objectives will teach readers: How operations and production systems are designed and planned How operations and production systems are engineered and optimized How to formulate and solve manufacturing systems problems How to model and solve interdisciplinary and systems engineering problems How to solve decision problems with multiple and conflicting objectives This book is ideal for senior undergraduate, MS, and PhD graduate students in all fields of engineering, business, and management as well as practitioners and researchers in systems engineering, operations, production, and manufacturing.