Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's «Toxicity Testing in the 21st Century: A Vision and Strategy» and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing is divided into five parts: General aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailed information about data generation, data analysis, and applications in risk assessment. The authors not only enumerate the advantages of each high-throughput method over comparable conventional methods, but also point out the high-throughput method's limitations and potential pitfalls. In addition, the authors describe current research efforts to make high-throughput toxicity screening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures and illustrations to help them understand and perform the latest high-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers who need to implement high-throughput screening methods for toxicity testing in their laboratories as well as for researchers who need to evaluate the data generated by these methods.
An updated overview of the rapidly developing field of green engineering techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
The Toxicology of Methanol presents a single source of information and an understanding of the toxicity of methanol from animal data, potential environmental effects as well as human effects. The animal data, which goes to making up the majority of the data on the toxicity of methanol and the mechanism of action, is reviewed as it relates to the potential toxicity in humans.
Now you can score higher in chemistry Every high school requires a course in chemistry for graduation, and many universities require the course for majors in medicine, engineering, biology, and various other sciences. U Can: Chemistry I For Dummies offers all the how-to content you need to enhance your classroom learning, simplify complicated topics, and deepen your understanding of often-intimidating course material. Plus, you'll find easy-to-follow examples and hundreds of practice problems—as well as access to 1,001 additional Chemistry I practice problems online! As more and more students enroll in chemistry courses,, the need for a trusted and accessible resource to aid in study has never been greater. That's where U Can: Chemistry I For Dummies comes in! If you're struggling in the classroom, this hands-on, friendly guide makes it easy to conquer chemistry. Simplifies basic chemistry principles Clearly explains the concepts of matter and energy, atoms and molecules, and acids and bases Helps you tackle problems you may face in your Chemistry I course Combines 'how-to' with 'try it' to form one perfect resource for chemistry students If you're confused by chemistry and want to increase your chances of scoring your very best at exam time, U Can: Chemistry I For Dummies shows you that you can!
Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described.
Physical Inorganic Chemistry contains the fundamentals of physical inorganic chemistry, including information on reaction types, and treatments of reaction mechanisms. Additionally, the text explores complex reactions and processes in terms of energy, environment, and health. This valuable resource closely examines mechanisms, an under-discussed topic. Divided into two sections, researchers, professors, and students will find the wide range of topics, including the most cutting edge topics in chemistry, like the future of solar energy, catalysis, environmental issues, climate changes atmosphere, and human health, essential to understanding chemistry.
Discover the science of beer and beer making Ever wondered just how grain and water are transformed into an effervescent, alcoholic beverage? From prehistory to our own time, beer has evoked awe and fascination; it seems to have a life of its own. Whether you're a home brewer, a professional brewer, or just someone who enjoys a beer, The Chemistry of Beer will take you on a fascinating journey, explaining the underlying science and chemistry at every stage of the beer making process. All the science is explained in clear, non-technical language, so you don't need to be a PhD scientist to read this book and develop a greater appreciation for the world's most popular alcoholic drink. The Chemistry of Beer begins with an introduction to the history of beer and beer making. Author Roger Barth, an accomplished home brewer and chemistry professor, then discusses beer ingredients and the brewing process. Next, he explores some core concepts underlying beer making. You'll learn chemistry basics such as atoms, chemical bonding, and chemical reactions. Then you'll explore organic chemistry as well as the chemistry of water and carbohydrates. Armed with a background in chemistry principles, you'll learn about the chemistry of brewing, flavor, and individual beer styles. The book offers several features to help you grasp all the key concepts, including: Hundreds of original photographs and line drawings Chemical structures of key beer compounds Glossary with nearly 1,000 entries Reference tables Questions at the end of each chapter The final chapter discusses brewing at home, including safety issues and some basic recipes you can use to brew your own beer. There's more to The Chemistry of Beer than beer. It's also a fun way to learn about the science behind our technology and environment. This book brings life to chemistry and chemistry to life.
Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison – and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia – it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include: chemistry of As, Sb and Bi biological chemistry of arsenic biological chemistry of Sb and Bi arsenic and antimony speciation in environmental and biological samples arsenic in traditional chinese medicine arsenic in aquifers biomethylation of As, Sb and Bi uptake of metalloids by cells bismuth complexes of porphyrins and their potential in medical applications Helicobacter pylori and bismuth metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients anticancer properties of As, Sb and Bi radio-Bi in cancer therapy genotoxicity of As, Sb and Bi metallomics as a new technique for As, Sb and Bi metalloproteomics for As, Sb and Bi Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.
The manual presents general information on the chemistry, pedochemistry, and geochemistry of aluminum, considers the main groups of aluminum compounds in the soil solid phase and the soil solution, as well as processes with the participation of mobile aluminum in the soils of humid extratropical regions. Special attention is given to the toxic properties of aluminum compounds, as well as toxic effects and parameters for the estimation of the toxicity of aluminum compounds. Methods for the determination of toxic aluminum compounds in soil solutions and surface waters. The manual can be used for the courses of lectures in Soil Science, Soil Chemistry, and Ecology.
If you are a parent struggling to help your child with chemistry homework, this is a short book that will help you. It covers key chemistry topics: Oxides, Bases, Acids, Salts, Equivalent proportions, Acid Base reactions, Weight and Volume problems, Equilibrium, Le Chatelier’s Principle, Freezing and Boiling points, Balance Redox Reactions, Stoichiometry (with answers and solutions).If you are student, read this book and you will prove to yourself that you can understand chemistry!
Chemistry For Dummies, 2nd Edition (9781119293460) was previously published as Chemistry For Dummies, 2nd Edition (9781118007303). While this version features a new Dummies cover and design, the content is the same as the prior release and should not be considered a new or updated product. See how chemistry works in everything from soaps to medicines to petroleum We're all natural born chemists. Every time we cook, clean, take a shower, drive a car, use a solvent (such as nail polish remover), or perform any of the countless everyday activities that involve complex chemical reactions we're doing chemistry! So why do so many of us desperately resist learning chemistry when we're young? Now there's a fun, easy way to learn basic chemistry. Whether you're studying chemistry in school and you're looking for a little help making sense of what's being taught in class, or you're just into learning new things, Chemistry For Dummies gets you rolling with all the basics of matter and energy, atoms and molecules, acids and bases, and much more! Tracks a typical chemistry course, giving you step-by-step lessons you can easily grasp Packed with basic chemistry principles and time-saving tips from chemistry professors Real-world examples provide everyday context for complicated topics Full of modern, relevant examples and updated to mirror current teaching methods and classroom protocols, Chemistry For Dummies puts you on the fast-track to mastering the basics of chemistry.
A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.
The past, present, and future of green chemistry and green engineering From college campuses to corporations, the past decade witnessed a rapidly growing interest in understanding sustainable chemistry and engineering. Green Chemistry and Engineering: A Practical Design Approach integrates the two disciplines into a single study tool for students and a practical guide for working chemists and engineers. In Green Chemistry and Engineering, the authors—each highly experienced in implementing green chemistry and engineering programs in industrial settings—provide the bottom-line thinking required to not only bring sustainable chemistry and engineering closer together, but to also move business towards more sustainable practices and products. Detailing an integrated, systems-oriented approach that bridges both chemical syntheses and manufacturing processes, this invaluable reference covers: Green chemistry and green engineering in the movement towards sustainability Designing greener, safer chemical synthesis Designing greener, safer chemical manufacturing processes Looking beyond current processes to a lifecycle thinking perspective Trends in chemical processing that may lead to more sustainable practices The authors also provide real-world examples and exercises to promote further thought and discussion. The EPA defines green chemistry as the design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Green engineering is described as the design, commercialization, and use of products and processes that are feasible and economical while minimizing both the generation of pollution at the source and the risk to human health and the environment. While there is no shortage of books on either discipline, Green Chemistry and Engineering is the first to truly integrate the two.
The easy way to get a grip on inorganic chemistry Inorganic chemistry can be an intimidating subject, but it doesn't have to be! Whether you're currently enrolled in an inorganic chemistry class or you have a background in chemistry and want to expand your knowledge, Inorganic Chemistry For Dummies is the approachable, hands-on guide you can trust for fast, easy learning. Inorganic Chemistry For Dummies features a thorough introduction to the study of the synthesis and behavior of inorganic and organometallic compounds. In plain English, it explains the principles of inorganic chemistry and includes worked-out problems to enhance your understanding of the key theories and concepts of the field. Presents information in an effective and straightforward manner Covers topics you'll encounter in a typical inorganic chemistry course Provides plain-English explanations of complicated concepts If you're pursuing a career as a nurse, doctor, or engineer or a lifelong learner looking to make sense of this fascinating subject, Inorganic Chemistry For Dummies is the quick and painless way to master inorganic chemistry.
The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.