This is a cross sectional study on 400 cases of diabetes mellitus who attended the National Diabetic centre/ AL–Mustensyria university for a period of 6 months. The main factor of metabolic syndrome was dysglycaemia followed by hypertension, obesity and dyslipidaemia. Females in this study were more prone to have metabolic syndrome; Male: Female ratio = 0.5. Those in the age group 60-69 have the highest frequency of metabolic syndrome. Those with BMI 30-40 have the highest frequency of metabolic syndrome. Conclusion: This study concludes that early diagnosis and aggressive treatment is needed for metabolic syndrome to avoid cardiovascular complications. This study is important because of its predictive power for cardiovascular complication and diabetes.
The metabolic syndrome a concurrence of disturbed glucose and insulin metabolism, overweight and abdominal fat distribution, dyslipidemia and hypertension, is associated with subsequent development of type 2 diabetes mellitus and cardiovascular disease (CVD). Despite its high prevalence in Asians, no national estimate is currently available on the metabolic syndrome in patients with acute myocardial infarction in Pakistan.A matched case control study using questionnaire and analysis of components of metabolic syndrome was carried out at tertiary care hospitals of Peshawar Pakhtunkhwa.The result showed that patients were 6.19 times more likely to have three or more diagnostic criteria of metabolic syndrome than the controls i.e. 55% vs 17%. This study contributed to the fact that metabolic syndrome is more common in patients with acute myocardial infarction. Screening of adults with central obesity for other parameters of the metabolic syndrome may help to reduce the prevalence of metabolic syndrome as well of myocardial infarction at an early age, which is the complication of metabolic syndrome.
The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndrome Bariatric surgery for obesity Fitness Brain insulin resistance and appetite The nature of the insulin resistance seen in metabolic syndrome. This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.
The prevalence of the metabolic syndrome increases after the onset of menopause, and may explain in part the apparent acceleration of cardiovascular disease in postmenopausal women.The objectives of this study is to determine the prevalence of metabolic syndrome among postmenopausal women and its associated factors at Gynaecology clinic Hospital Universiti Sains Malaysia.This is a cross sectional study involving 411 women and metabolic syndrome was defined in accordance with criteria of International Diabetic Federation (IDF). The prevalence of metabolic syndrome was 36.7%. The risk of metabolic syndrome detection (univariate analysis) increased with presence of obstetric history of HPT (odds ratio (OR) 2.64, 95% (CI) 1.25-5.62), family history of HPT (odds ratio (OR) 1.71 , 95% (CI) 1.13-2.59) and obesity (odds ratio (OR) 2.59, 95% (CI) 1.08-6.23 ), and the usage of contraception (odds ratio (OR) 1.56, 95% (CI)1.02-2.42). Screening for metabolic syndrome in postmenopausal women is important for early identification and aggressive management.
Recent reports point to the fact that metabolic syndrome is only modestly associated with cardiovascular disease risk. The life- course of socioeconomic position appears to be an important cofounder in that association. Since studies that relate socio-economic and metabolic syndrome appear not to be available in the developing nations, this study therefore investigated the association between socioeconomic and prevalence of Metabolic syndrome Nigeria.
The metabolic syndrome is a complex cardiometabolic cluster characterized by hyperinsulinaemia, low glucose tolerance, dyslipidaemia, hypertension and obesity. It represents a significant marker of increased risk for both cardiovascular disease and type 2 diabetes. To fight efficiently the forecasted type 2 diabetes and its cardiovascular and metabolic complications, evidence-based strategies, focusing on target groups at risk, are needed to tailor prevention programs. In this context, the overall aim of this work was to investigate, for the first time, the epidemiological profile of the metabolic syndrome, its variations and its potential socioeconomic, behavioral and biological determinants among the adult population residing in Luxembourg. Such data should offer new possibilities for successful intervention to prevent and treat the metabolic syndrome before the coronary heart disease and type 2 diabetes develop in susceptible individuals and groups.
Metabolic Syndrome refers to the clustering of risk factors including obesity, elevated blood pressure (hypertension), elevated blood sugars, dyslipidaemia (high triglycerides & low HDL concentration) and hence increased risk for developing many serious medical conditions including type 2 diabetes, myocardial infarction, and stroke & early death. Lifestyle changes, one of the main factor, due to fast increasing urbanization, especially in developing countries like India, has led to the development of serious health problems like obesity, hypertension, diabetes, etc. which in turn lead to the complications like Metabolic Syndrome . About one third of the urban population in India’s major cities have Metabolic Syndrome. The National Cholesterol Education Program Adult Treatment Panel III simplified the definition of Metabolic Syndrome to make it user friendly for medical practitioners. Our study included faculty members of different professional streams using NCEP ATPIII criteria and was concluded that medical faculty had maximum percentage of subjects having Metabolic Syndrome. Early lifestyle modification leads to the reduction in these risk factors and hence to Metabolic Syndrome.
The metabolic syndrome (MS), also known as syndrome X, was described in 1988 as a special pathological entity among the metabolic diseases by Gerald Raven. By its very existence it drew the attention of numerous researches all over the world. The large interest that this mysterious named entity has caused can be understood by the influence of its components that are the leading diseases of the modern civilization, such as the disorder in the glucose metabolism, fats, hypertension and the increased development of cardiovascular diseases because of increased process of atherosclerosis.
This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.
Nurses who are mostly shift workers were found to be at risk for coronary heart disease (CHD). A cross sectional study was conducted among 404 female nurses working in a teaching hospital in Kelantan, Malaysia to determine the prevalence of metabolic syndrome and its associated factors. Data were collected using a proforma consisted of sociodemographic data, occupational history, physical activity and DASS 42 questionnaire (validated Malay version). Anthropometric, blood pressure measurement and fasting venous blood were taken from each subject for fasting lipid profile and blood sugar. The prevalence of metabolic syndrome was 24.3% (95% CI: 20.1, 28.4). The significant factors associated with metabolic syndrome were total duration of employment (years) and one way commuting time to work (minutes). High prevalence of metabolic syndrome indicates that nurses are occupational high risk group for CHD. Occupational factors which significantly associated with metabolic syndrome in this study are total duration of employment and one way commuting time to work, however there is no significant relationship between metabolic syndrome and shift work as well as self-perceived job stress.
" Are psoriasis and metabolic syndrome offshoots of the same root?" is a small exercise to make a scientific understanding of etiological association of the two processes. Although a good beginning, still lot of research is needed in this field. C-reactive protein, a marker of inflammation, can be used to sort out those psoriatic patients who are likely to benefit from therapy by biological agents and can also help to delineate those psoriatic patients who are at high risk of developing a metabolic syndrome.
This publication is devoted to the pressing problems of metabolic syndrome and their scrutiny. Data presented includes fresh information on classification and diagnostics of glucose homeostasis abnormalities, physiology and pathophysiology of glucose metabolism and lipid exchange. The treatment of metabolic syndrome manifestations has become a critical issue. The book includes findings on etiology and pathogenesis of the syndrome and introduces up-to-date treatment methods. A separate chapter presents material on hypolipidemic therapy in the course of the syndrome. The book is intended for the use in professional education, further training of general practitioners and by students of medical schools.
Chronic Obstructive Pulmonary Diseases (COPD) are thought to have increased association with Metabolic Syndrome which represents a cluster of factors that increase the risk of cardiovascular diseases and diabetes mellitus. However, the extent of association of COPD with Metabolic Syndrome and its individual components are still an unsettled issue and it is likely to vary from population to population. Under the above context the present book was written to explore the association of Metabolic Syndrome and its components with COPD.
Metabolic syndrome is a modern era disease which has engulfed wide regions of the world and the problem is increasing at a rapid pace. The atherogenic dyslipidemia associated with the metabolic syndrome predispose to cardiovascular events. The Statins are considered first-line therapy for treating Dyslipidemia. Clinical response to statins is highly variable and genetic factors play an important role. Sterol regulatory element binding factors (SREBF) – SREBF Cleavage Activating Protein (SCAP) pathway play important roles in lipid metabolism and homeostasis. Identification of genes & genetic variants that influence statin responsiveness holds promise for a safe and effective treatment of Dyslipidemia in Metabolic syndrome.
Metabolic syndrome continues to be one of the major causes of mortality and morbidity in populations worldwide with an ever increasing incidence due to dietary and lifestyle changes. Statins are widely prescribed in patients of Metabolic syndrome for treatment of dyslipidemia and other pleiotropic effects. Rosuvastatin also called as superstatin, is a newer analogue with less number of studies especially in the Indian population. This book evaluates whether Rosuvastatin alone, or a combination of Atorvastatin and Ezetimibe would be a better alternative in treating dyslipidemia in patients of Metabolic syndrome. This book is beneficial to both clinicians as well as academicians. It helps the clinicians to choose a better alternative depending on the patient characteristics and helps basic medical scientists to pursue further research in this domain.