An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.
Clinical Dilemmas in Viral Liver Disease is a practical up-to-date handbook providing answers to the questions and challenges that arise in day-to-day practice. Each short chapter addresses a different topic and provides evidence-based guidance on subjects ranging from optimizing current management through to special management problems and novel treatments. This book is suitable for all medical professionals involved in the care of patients with viral liver disease: established and trainee hepatologists, pediatric hepatologists, pathologists, radiologists, transplant surgeons and nurse specialists
Pediatric respiratory disorders are responsible for a number of acute and chronic health conditions and are a leading cause of pediatric emergency room visits and hospitalizations. More than ever, nurses and nurse practitioners must have an understanding of the anatomy, pathophysiology, diagnosis and state of the art treatments in pediatric respiratory disease as they are often the first to come in contact with and recognize respiratory problems in children. Nursing Care in Pediatric Respiratory Disease seeks to provide both nurses and nurse practitioners with this information in order to aid them in the diagnosis and treatment of children suffering from acute and chronic respiratory disorders. Nursing Care in Pediatric Respiratory Disease opens with an overview of the anatomy and physiology of the respiratory system, best practices for assessing respiratory symptoms in children, and common respiratory therapies and treatment methods. It then proceeds through an examination of varying acute and chronic upper and lower respiratory diseases spanning from asthma and cystic fibrosis to vocal cord paralysis and sinusitis in both hospital and ambulatory settings. Nursing Care in Pediatric Respiratory Disease provides nurses and other health care providers with a comprehensive and practical resource which allows them to collaborate and advocate more effectively, as well as educate both the family and child in management of respiratory disorders.
"Reversing Gum Disease Naturally presents techniques and information so that you can reverse already unhealthy states in your mouth or prevent the onset of gum disease. Sandra Senzon enhances patients' oral health through traditional as well as holistic methods." –Barry Musikant, D.M.D. «This book allows the patient to be an active participant along with healthcare professionals.» –Jay P. Goldsmith, D.M.D. «There is a ray of hope at the end of the tunnel for all those who suffer from gum disease. We ultimately don't have to lose our natural teeth. Sandra Senzon shows us the many ways in which the mouth is connected to the body, and how, with the use of natural herbal products and proper mechanic techniques, you can reverse gum disease naturally.» –Joseph P. Green, D.O.S. Gum disease is the #1 oral health issue for Americans today-and simply brushing and flossing are not enough to avoid it. In this unique book, registered dental hygienist Sandra Senzon reveals how you can prevent and reverse gum disease through natural treatments. You'll get a new and broader understanding of your mouth as Senzon explains the causes of gum disease, along with the roles that stress, diet, and certain conditions such as diabetes can play in the onset of the disease. She shows you how to work with holistic products, set up an at-home hygiene center, and find the right professional to guide you in the natural reversal of gum disease. There's even a section for parents on how to help children practice good oral hygiene. Packed with expert tips and motivational strategies, Reversing Gum Disease Naturally will enable you to keep your gums and your teeth healthy and strong.
DVDIn The FleshThe Happiest Days Of Our LivesAnother Brick In The Wall (part 2) MotherGet Your Filthy Hands Off My DesertSouthampton DockPigs On The Wing (part 1)DogsWelcome To The MachineWish You Were HereShine On You Crazy Diamond (parts 1-8)Set The Controls For The Heart Of The SunBreathe (in the air)TimeMoneyThe Pros And Cons Of Hitch Hiking (part 11)Perfect Sense (parts I and II)The Bravery Of Being Out Of RangeIt's A Miracle Amused To Death Brain DamageEclipseComfortably NumbEach Small Candle
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
A detailed look at the latest research in non-invasive in vivo cytometry and its applications, with particular emphasis on novel biophotonic methods, disease diagnosis, and monitoring of disease treatment at single cell level in stationary and flow conditions. This book thus covers the spectrum ranging from fundamental interactions between light, cells, vascular tissue, and cell labeling particles, to strategies and opportunities for preclinical and clinical research. General topics include light scattering by cells, fast video microscopy, polarization, laser-scanning, fluorescence, Raman, multi-photon, photothermal, and photoacoustic methods for cellular diagnostics and monitoring of disease treatment in living organisms. Also presented are discussions of advanced methods and techniques of classical flow cytometry.
The control of diseases in crops is still largely dominated by the use of fungicides, but with the increasing incidence of fungicide resistance, plus mounting concern for the environment resulting from excessive agrochemical use, the search for alternative, reliable methods of disease control is gaining momentum. The purpose of this important book is to examine the development and exploitation (or potential for exploitation) of a range of non-chemical approaches to disease control, with a focus on the need for a greater understanding of crop ecology as the basis for effective disease control in the field. Chapters in the book, written by international experts in the subject area, include coverage of: biological control methods host-plant resistance the exploitation of tolerance and the use of bacteriophages Carefully edited by Professor Dale Walters, widely respected for his work in the area of crop protection, Disease Control in Crops is an essential reference book for plant pathologists, microbiologists, plant and agricultural scientists and crop protection specialists, including those working within, and providing consultancy to, the agrochemical industries. Libraries in all universities and research establishments where biological sciences and agriculture are studied and taught should have copies of this timely publication on their shelves.