This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 58 continues to report recent advances with a significant, up-to-date selection of contributions by internationally-recognized researchers. The chapters of this volume are devoted to the following topics: • Tris(dithiolene) Chemistry: A Golden Jubilee • How to find an HNO needle in a (bio)-chemical Haystack • Photoactive Metal Nitrosyl and Carbonyl Complexes Derived from Designed Auxiliary Ligands: An Emerging Class of Photochemotherapeutics • Metal–Metal Bond-Containing Complexes as Catalysts for C–H Functionalization Iron Catalysis in Synthetic Chemistry • Reactive Transition Metal Nitride Complexes Suitable for inorganic chemists and materials scientists in academia, government, and industries including pharmaceutical, fine chemical, biotech, and agricultural.
Transition metals open up new opportunities for synthesis, because their means of bonding and their reaction mechanisms differ from those of the elements of the s and p blocks. In the last two decades the subject has mushroomed – established reactions are seeing both technical improvements and increasing numbers of applications, and new reactions are being developed. The practicality of the subject is demonstrated by the large number of publications coming from the process development laboratories of pharmaceutical companies, and its importance is underlined by the fact that three Nobel prizes have been awarded for discoveries in this field in the 21st Century already. Organic Synthesis Using Transition Metals, 2nd Edition considers the ways in which transition metals, as catalysts and reagents, can be used in organic synthesis, both for pharmaceutical compounds and for natural products. It concentrates on the bond-forming reactions that set transition metal chemistry apart from «classical» organic chemistry. Each chapter is extensively referenced and provides a convenient point of entry to the research literature. Topics covered include: introduction to transition metals in organic synthesis coupling reactions C-H activation carbonylative coupling reactions alkene and alkyne insertion reactions electrophilic alkene and alkyne complexes reactions of alkyne complexes carbene complexes h3- or p-allyl -allyl complexes diene, dienyl and arene complexes cycloaddition and cycloisomerisation reactions For this second edition the text has been extensively revised and expanded to reflect the significant improvements and advances in the field since the first edition, as well as the large number of new transition metal-catalysed processes that have come to prominence in the last 10 years – for example the extraordinary progress in coupling reactions using “designer” ligands, catalysis using gold complexes, new opportunities arising from metathesis chemistry, and C-H activation – without neglecting the well established chemistry of metals such as palladium. Organic Synthesis Using Transition Metals, 2nd Edition will find a place on the bookshelves of advanced undergraduates and postgraduates working in organic synthesis, catalysis, medicinal chemistry and drug discovery. It is also useful for practising researchers who want to refresh and enhance their knowledge of the field.
Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.
Filling the need for a comprehensive treatment that covers the theory, methods and the different types of metal ion complexes with water (hydrolysis), this handbook and ready reference is authored by a nuclear chemist from academia and an industrial geochemist. The book includes both cation and anion complexes, and approaches the topic of metal ion hydrolysis by first covering the background, before proceeding with an overview of the dissociation of water and then all different metal-water hydrolysis complexes and compounds. A must-have for scientists in academia and industry working on this interdisciplinary topic.
This book provides an overview of bioinspired metal-sulfur catalysis by covering structures, activities and model complexes of enzymes exhibiting metal sulphur moieties in their active center.
A systematic analysis of electrochemical processes involving metal complexes. Starting with general considerations on equilibria in solutions and at interfaces as well as on mass transport, the text acquaints readers with the theory and common experimental practice for studying electrochemical reactions of metals complexes. The core part of the book deals with all important aspects of electroplating, including a systematic discussion of co-deposition of metals and formation of alloys. It also discusses such related subjects as oxide layer formation and hydrogen evolution as a side reaction.
The Organometallic Chemistry of N-heterocyclic Carbenes describes various aspects of N-heterocyclic Carbenes (NHCs) and their transition metal complexes at an entry level suitable for advanced undergraduate students and above. The book starts with a historical overview on the quest for carbenes and their complexes. Subsequently, unique properties, reactivities and nomenclature of the four classical NHCs derived from imidazoline, imidazole, benzimidazole and 1,2,4-triazole are elaborated. General and historically relevant synthetic aspects for NHCs, their precursors and complexes are then explained. The book continues with coverage on the preparation and characteristics of selected NHC complexes containing the most common metals in this area, i.e. Ni, Pd, Pt, Ag, Cu, Au, Ru, Rh and Ir. The book concludes with an overview and outlook on the development of various non-classical NHCs beyond the four classical types. Topics covered include: Stabilization, dimerization and decomposition of NHCs Stereoelectronic properties of NHCs and their evaluation Diversity of NHCs Isomers of NHC complexes and their identification NMR spectroscopic signatures of NHC complexes normal, abnormal and mesoionic NHCs The Organometallic Chemistry of N-heterocyclic Carbenes is an essential resource for all students and researchers interested in this increasingly important and popular field of research.
Written by an experienced editor widely acclaimed within the scientific community, this book covers everything from oxygen to nitrogen functionalities. From the contents: * Palladium-Catalyzed Syntheses of Five-Membered Saturated Heterocycles * The Formation of Carbon-Sulfur and Carbon-Selenium Bonds by Substitution and Addition Reactions Catalyzed by Transition Metal Complexes * Palladium-Catalysis for Oxidative 1,2-Difunctionalization of Alkenes * Palladium-Catalyzed Formation of Aromatic Heterocycles * Rhodium-Catalyzed Amination of C-H-Bonds * Transition Metal-Catalyzed Synthesis of Heterocycles * Copper-Catalyzed Synthesis of Azoles * Palladium(II)-Catalyzed C-N Bond Formation Involving Aminopalladation of Aklenes * Carbon-Heteroatom Bond Formation by Rh(I)-Catalyzed Ring-Opening Reactions * Recent Advances in Homogeneous Gold Catalysis: Formation of Carbon-Heteroatom Bonds The result is an indispensable source of information for the strategic planning of the synthetic routes for organic, catalytic and medicinal chemists, as well as chemists in industry.
Inorganic Chemistry for Geochemistry and Environmental Sciences: Fundamentals and Applications discusses the structure, bonding and reactivity of molecules and solids of environmental interest, bringing the reactivity of non-metals and metals to inorganic chemists, geochemists and environmental chemists from diverse fields. Understanding the principles of inorganic chemistry including chemical bonding, frontier molecular orbital theory, electron transfer processes, formation of (nano) particles, transition metal-ligand complexes, metal catalysis and more are essential to describe earth processes over time scales ranging from 1 nanosec to 1 Gigayr. Throughout the book, fundamental chemical principles are illustrated with relevant examples from geochemistry, environmental and marine chemistry, allowing students to better understand environmental and geochemical processes at the molecular level. Topics covered include: • Thermodynamics and kinetics of redox reactions • Atomic structure • Symmetry • Covalent bonding, and bonding in solids and nanoparticles • Frontier Molecular Orbital Theory • Acids and bases • Basics of transition metal chemistry including • Chemical reactivity of materials of geochemical and environmental interest Supplementary material is provided online, including PowerPoint slides, problem sets and solutions. Inorganic Chemistry for Geochemistry and Environmental Sciences is a rapid assimilation textbook for those studying and working in areas of geochemistry, inorganic chemistry and environmental chemistry, wishing to enhance their understanding of environmental processes from the molecular level to the global level.
A one-stop resource for understanding and applying polymerization catalysts An edited volume featuring contributions from leading researchers, the Handbook of Transition Metal Polymerization Catalysts covers the design and synthesis of catalysts, and their applications in synthesis of polymers. Dealing with those polymerization catalysts that afford commercially acceptable yields of polymer with respect to catalyst mass and promising newer catalysts, this practical reference provides polymer and organic chemists with a comprehensive overview of the known methods for developing and applying these important catalysts. With both recent advances and historically important catalysts, the subjects covered in this text include: Metal alkyls and other compounds that function as co-catalysts with a large number of catalysts The varieties of porous silica either necessary or valuable in certain catalyst formulations Catalyst scale-up and commercialization Copper catalysts for olefin polymerization Morphology control Along with the above topics, the Handbook of Transition Metal Polymerization Catalysts provides tables of valuable data to assist in reproducing a synthesis or applying the knowledge to a new problem. Polymerization reactivities, polymer properties, monomer and solvent purity requirements, molecular weights, distribution, and reactivity ratios are also covered. The Handbook of Transition Metal Polymerization Catalysts offers an excellent one-stop resource for understanding and applying polymerization catalysts.
Homogeneous catalysis by soluble metal complexes has gained considerable attention due to its unique applications and features such as high activity and selectivity. Catalysis of this type has demonstrated impressive achievements in synthetic organic chemistry and commercial chemical technology. Homogeneous Catalysis with Metal Complexes: Kinetic Aspects and Mechanisms presents a comprehensive summary of the results obtained over the last sixty years in the field of the kinetics and mechanisms of organic and inorganic reactions catalyzed with metal complexes. Topics covered include: Specific features of catalytic reaction kinetics in the presence of various mono- and polynuclear metal complexes and nanoclusters Multi-route mechanisms and the methods of their identification, as well as approaches to the kinetics of polyfunctional catalytic systems Principles and features of the dynamic behavior of nonlinear kinetic models The potential, achievements, and limitations of applying the kinetic approach to the identification of complex reaction mechanisms The development of a rational strategy for designing kinetic models The kinetic models and mechanisms of many homogeneous catalytic processes employed in synthetic and commercial chemistry Written for specialists in the field of kinetics and catalysis, this book is also relevant for post-graduates engaged in the study
Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.
An essential reference to the highly effective reactions applied to modern organic synthesis Rhodium complexes are one of the most important transition metals for organic synthesis due to their ability to catalyze a variety of useful transformations. Rhodium Catalysis in Organic Synthesis: Methods and Reactions explores the most recent progress and new developments particularly in the field of catalytic cyclization reactions using rhodium(I) complexes and catalytic carbon-hydrogen bond activation reactions using rhodium(II) and rhodium(III) complexes. Edited by a noted expert in the field with contributions from a panel of leading international scientists, Rhodium Catalysis in Organic Synthesis: Methods and Reactions presents the essential information in one comprehensive volume. Designed to be an accessible resource, the book is arranged by different reaction types. All the chapters provide insight into each transformation and include information on the history, selectivity, scope, mechanism, and application. In addition, the chapters offer a summary and outlook of each transformation. This important resource: Offers a comprehensive review of how rhodium complexes catalyze a variety of highly useful reactions for organic synthesis (e.g. coupling reactions, CH-bond functionalization, hydroformylation, cyclization reactions and others) Includes information on the most recent developments that contain a range of new, efficient, elegant, reliable and useful reactions Presents a volume edited by one of the international leading scientists working in the field today Contains the information that can be applied by researchers in academia and also professionals in pharmaceutical, agrochemical and fine chemical companies Written for academics and synthetic chemists working with organometallics, Rhodium Catalysis in Organic Synthesis: Methods and Reactions contains the most recent information available on the developments and applications in the field of catalytic cyclization reactions using rhodium complexes.
This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
This volume of Inorganic Syntheses spans the preparations of wide range of important inorganic, organometallic and solid-state compounds. The volume is divided into 6 chapters. The first chapter contains the syntheses of some key early transition metal halide clusters and the very useful mononuclear molybdenum(III) synthon, MoCl3(THF)3. Chapter 2 covers the synthesis of a number of cyclopentadienyl compounds, including a novel route to sodium and potassium cyclopentadienide, MC5H5. Chapter 3 details synthetic procedures for a range of metal-metal bonded compounds, including several with metal-metal multiple bonds. Chapter 4 contains procedures for a range of early and late transition metal compounds, each a useful synthon for further synthetic elaboration. Chapter 5 deals with the synthesis of a number of main group compounds and ligands, while Chapter 6 covers teaching laboratory experiments.